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- W2559920616 abstract "A new hybrid template has been designed by integrating the structural features of nimesulide and the 1,2,3-triazole moiety in a single molecular entity at the same time eliminating the problematic nitro group of nimesulide. The template has been used for the generation of a library of molecules as potential anticancer agents. A mild and greener CuAAC approach has been used to synthesize these compounds via the reaction of 4-azido derivative of nimesulide and terminal alkynes in water. Three of these compounds showed promising growth inhibition (IC50 ∼6-10μM) of A549, HepG2, HeLa and DU145 cancer cell lines but no significant effects on HEK293 cell line. They also inhibited PDE4B in vitro (60-70% at 10μM) that was supported by the docking studies (PLP score 87-94) in silico." @default.
- W2559920616 created "2016-12-16" @default.
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- W2559920616 date "2017-02-01" @default.
- W2559920616 modified "2023-09-27" @default.
- W2559920616 title "1,2,3-Triazole-nimesulide hybrid: Their design, synthesis and evaluation as potential anticancer agents" @default.
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- W2559920616 doi "https://doi.org/10.1016/j.bmcl.2016.12.030" @default.
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