FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559925285> ?p ?o ?g. }

• W2559925285 endingPage "204" @default.
• W2559925285 startingPage "196" @default.
• W2559925285 abstract "The Polycomb/Trithorax Responsive Elements (PRE/TREs) are the cis-regulatory sequences that interact with both repressive (PcG) as well as activating (TrxG) complexes. However, most of the mammalian PREs are demonstrated to interact with the repressive polycomb (PcG) complexes only. We have carried out an unbiased search for proteins interacting with human PRE-PIK3C2B (hPRE-PIK3C2B) based on DNA affinity purification followed by mass spectrometry and identified MLL, MLL4 and WDR87 among other proteins in three biological replicates in HEK, U87 and HeLa cell lines. The hPRE-PIK3C2B interacts with the members of multiple activating complexes (COMPASS-like). The increase in the interaction of MLL and MLL4 on depletion of YY1 and the increase in the enrichment of YY1 and EZH2 upon MLL knockdown at the hPRE-PIK3C2B indicate the dual occupancy and suggest a concentration dependent enrichment of the activator or the repressor complex at hPRE-PIK3C2B. Further, we show that the hPRE-PIK3C2B interacts with the Drosophila homologues of PcG and TrxG proteins in transgenic flies. Here, we found that there is an increased enrichment of Pc (Polycomb) in comparison to Trx (TrxG protein) at hPRE-PIK3C2B in the Drosophila transgenic flies and this seems to be the default state while the balance is tipped towards the trithorax complex in PcG mutants. To the best of our knowledge, this is one of the early demonstrations of human PRE acting as a TRE without any sequence alteration." @default.
• W2559925285 created "2016-12-16" @default.
• W2559925285 creator A5007761510 @default.
• W2559925285 creator A5011793273 @default.
• W2559925285 creator A5018835356 @default.
• W2559925285 creator A5032776326 @default.
• W2559925285 creator A5047120878 @default.
• W2559925285 date "2017-02-01" @default.
• W2559925285 modified "2023-09-25" @default.
• W2559925285 title "Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression" @default.
• W2559925285 cites W1488340603 @default.
• W2559925285 cites W1567410794 @default.
• W2559925285 cites W1577134718 @default.
• W2559925285 cites W1820935146 @default.
• W2559925285 cites W1862097217 @default.
• W2559925285 cites W1911331852 @default.
• W2559925285 cites W1920450187 @default.
• W2559925285 cites W1959535981 @default.
• W2559925285 cites W1963512312 @default.
• W2559925285 cites W1969149529 @default.
• W2559925285 cites W1969771659 @default.
• W2559925285 cites W1972170164 @default.
• W2559925285 cites W1976242511 @default.
• W2559925285 cites W1977289089 @default.
• W2559925285 cites W1977895957 @default.
• W2559925285 cites W1978992130 @default.
• W2559925285 cites W1986656413 @default.
• W2559925285 cites W1993165149 @default.
• W2559925285 cites W1995707267 @default.
• W2559925285 cites W2009277471 @default.
• W2559925285 cites W2010867623 @default.
• W2559925285 cites W2015132841 @default.
• W2559925285 cites W2019479916 @default.
• W2559925285 cites W2030427461 @default.
• W2559925285 cites W2030692936 @default.
• W2559925285 cites W2031373255 @default.
• W2559925285 cites W2038548460 @default.
• W2559925285 cites W2040290093 @default.
• W2559925285 cites W2047343415 @default.
• W2559925285 cites W2049868369 @default.
• W2559925285 cites W2050459843 @default.
• W2559925285 cites W2052741109 @default.
• W2559925285 cites W2058673308 @default.
• W2559925285 cites W2060870400 @default.
• W2559925285 cites W2064025098 @default.
• W2559925285 cites W2067707738 @default.
• W2559925285 cites W2071023317 @default.
• W2559925285 cites W2089760888 @default.
• W2559925285 cites W2094157761 @default.
• W2559925285 cites W2097148290 @default.
• W2559925285 cites W2119215188 @default.
• W2559925285 cites W2123337648 @default.
• W2559925285 cites W2125984352 @default.
• W2559925285 cites W2127614175 @default.
• W2559925285 cites W2129754968 @default.
• W2559925285 cites W2133400477 @default.
• W2559925285 cites W2140462087 @default.
• W2559925285 cites W2156798579 @default.
• W2559925285 cites W2164935229 @default.
• W2559925285 cites W2166114256 @default.
• W2559925285 cites W2208707498 @default.
• W2559925285 doi "https://doi.org/10.1016/j.bbagrm.2016.12.003" @default.
• W2559925285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27932267" @default.
• W2559925285 hasPublicationYear "2017" @default.
• W2559925285 type Work @default.
• W2559925285 sameAs 2559925285 @default.
• W2559925285 citedByCount "5" @default.
• W2559925285 countsByYear W25599252852017 @default.
• W2559925285 countsByYear W25599252852018 @default.
• W2559925285 countsByYear W25599252852019 @default.
• W2559925285 countsByYear W25599252852020 @default.
• W2559925285 countsByYear W25599252852022 @default.
• W2559925285 crossrefType "journal-article" @default.
• W2559925285 hasAuthorship W2559925285A5007761510 @default.
• W2559925285 hasAuthorship W2559925285A5011793273 @default.
• W2559925285 hasAuthorship W2559925285A5018835356 @default.
• W2559925285 hasAuthorship W2559925285A5032776326 @default.
• W2559925285 hasAuthorship W2559925285A5047120878 @default.
• W2559925285 hasConcept C101762097 @default.
• W2559925285 hasConcept C104317684 @default.
• W2559925285 hasConcept C143065580 @default.
• W2559925285 hasConcept C150194340 @default.
• W2559925285 hasConcept C153911025 @default.
• W2559925285 hasConcept C158448853 @default.
• W2559925285 hasConcept C173396325 @default.
• W2559925285 hasConcept C174510640 @default.
• W2559925285 hasConcept C186310378 @default.
• W2559925285 hasConcept C2777366897 @default.
• W2559925285 hasConcept C54355233 @default.
• W2559925285 hasConcept C81885089 @default.
• W2559925285 hasConcept C86339819 @default.
• W2559925285 hasConcept C86803240 @default.
• W2559925285 hasConcept C88045685 @default.
• W2559925285 hasConcept C95444343 @default.
• W2559925285 hasConceptScore W2559925285C101762097 @default.
• W2559925285 hasConceptScore W2559925285C104317684 @default.
• W2559925285 hasConceptScore W2559925285C143065580 @default.
• W2559925285 hasConceptScore W2559925285C150194340 @default.

• next