FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559942385> ?p ?o ?g. }

• W2559942385 endingPage "735" @default.
• W2559942385 startingPage "727" @default.
• W2559942385 abstract "Killer cell immunoglobulin-like receptors (KIRs) mediate natural killer cell function through interaction with their cognate human leukocyte antigen ligands. Thus, KIR gene variants have been implicated in resistance or susceptibility to viral infections. However, research on the role of these variants remains contradictory and inconclusive. In the present study, we investigated KIR gene content diversity and its association with human immunodeficiency virus (HIV) infection in an adult Black Zimbabwean population. Presence or absence of 15 KIR genes was determined in 189 HIV-infected adults and 97 HIV-uninfected blood donors using sequence specific primer polymerase chain reaction. Frequencies of KIR genes, genotypes, and haplotypes were compared between the cases and controls to identify putative associations between KIR gene variants and HIV status. We report in this study the frequencies of 15 KIR genes and 43 KIR genotypes (40 known and 3 novel) among Zimbabweans. Importantly, the frequency of the inhibitory KIR2DL2 gene was significantly higher in the uninfected group (62%) compared to the HIV-infected group (47%) (OR = 0.55, 95% CI: 0.33–0.90, p = 0.019). KIR2DL2/2DL2 homozygosity was also significantly higher in the uninfected group (35%) compared to HIV-infected group (53%) (OR = 0.33, 95% CI: 0.16–0.72, p = 0.005) under a recessive model. We conclude that the KIR2DL2 gene may be involved in protection against HIV infection. It may be possible that inhibitory KIR genes may have an important role to play in HIV acquisition among populations of African origin in whom the activating KIR genes are less frequent compared to among Caucasians." @default.
• W2559942385 created "2016-12-16" @default.
• W2559942385 creator A5001952688 @default.
• W2559942385 creator A5032837581 @default.
• W2559942385 creator A5035598800 @default.
• W2559942385 creator A5038108272 @default.
• W2559942385 creator A5038440890 @default.
• W2559942385 creator A5040124117 @default.
• W2559942385 creator A5041340560 @default.
• W2559942385 creator A5047773727 @default.
• W2559942385 creator A5050659589 @default.
• W2559942385 creator A5052976319 @default.
• W2559942385 creator A5063641482 @default.
• W2559942385 creator A5076485518 @default.
• W2559942385 creator A5078563557 @default.
• W2559942385 date "2016-12-01" @default.
• W2559942385 modified "2023-09-26" @default.
• W2559942385 title "<i>KIR</i> Gene Content Diversity in a Zimbabwean Population: Does <i>KIR2DL2</i> Have a Role in Protection Against Human Immunodeficiency Virus Infection?" @default.
• W2559942385 cites W1449209446 @default.
• W2559942385 cites W1483098386 @default.
• W2559942385 cites W1920437121 @default.
• W2559942385 cites W1959197364 @default.
• W2559942385 cites W1966402201 @default.
• W2559942385 cites W1967612314 @default.
• W2559942385 cites W1975088252 @default.
• W2559942385 cites W1993071851 @default.
• W2559942385 cites W1994481166 @default.
• W2559942385 cites W1996328190 @default.
• W2559942385 cites W1998020450 @default.
• W2559942385 cites W2001953450 @default.
• W2559942385 cites W2009328680 @default.
• W2559942385 cites W2009483826 @default.
• W2559942385 cites W2022915690 @default.
• W2559942385 cites W2023763939 @default.
• W2559942385 cites W2036402249 @default.
• W2559942385 cites W2049777459 @default.
• W2559942385 cites W2061439212 @default.
• W2559942385 cites W2073300038 @default.
• W2559942385 cites W2074244790 @default.
• W2559942385 cites W2084658117 @default.
• W2559942385 cites W2102161245 @default.
• W2559942385 cites W2128306333 @default.
• W2559942385 cites W2137675187 @default.
• W2559942385 cites W2143814503 @default.
• W2559942385 cites W2170090223 @default.
• W2559942385 cites W2171709048 @default.
• W2559942385 cites W2261195376 @default.
• W2559942385 cites W2300525012 @default.
• W2559942385 cites W2306289197 @default.
• W2559942385 cites W2339153584 @default.
• W2559942385 cites W2418884700 @default.
• W2559942385 cites W2801115101 @default.
• W2559942385 cites W3012050519 @default.
• W2559942385 cites W328199783 @default.
• W2559942385 cites W2299356800 @default.
• W2559942385 doi "https://doi.org/10.1089/omi.2016.0154" @default.
• W2559942385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27930093" @default.
• W2559942385 hasPublicationYear "2016" @default.
• W2559942385 type Work @default.
• W2559942385 sameAs 2559942385 @default.
• W2559942385 citedByCount "5" @default.
• W2559942385 countsByYear W25599423852017 @default.
• W2559942385 countsByYear W25599423852019 @default.
• W2559942385 countsByYear W25599423852021 @default.
• W2559942385 countsByYear W25599423852023 @default.
• W2559942385 crossrefType "journal-article" @default.
• W2559942385 hasAuthorship W2559942385A5001952688 @default.
• W2559942385 hasAuthorship W2559942385A5032837581 @default.
• W2559942385 hasAuthorship W2559942385A5035598800 @default.
• W2559942385 hasAuthorship W2559942385A5038108272 @default.
• W2559942385 hasAuthorship W2559942385A5038440890 @default.
• W2559942385 hasAuthorship W2559942385A5040124117 @default.
• W2559942385 hasAuthorship W2559942385A5041340560 @default.
• W2559942385 hasAuthorship W2559942385A5047773727 @default.
• W2559942385 hasAuthorship W2559942385A5050659589 @default.
• W2559942385 hasAuthorship W2559942385A5052976319 @default.
• W2559942385 hasAuthorship W2559942385A5063641482 @default.
• W2559942385 hasAuthorship W2559942385A5076485518 @default.
• W2559942385 hasAuthorship W2559942385A5078563557 @default.
• W2559942385 hasBestOaLocation W25599423852 @default.
• W2559942385 hasConcept C104317684 @default.
• W2559942385 hasConcept C135763542 @default.
• W2559942385 hasConcept C147483822 @default.
• W2559942385 hasConcept C150194340 @default.
• W2559942385 hasConcept C159047783 @default.
• W2559942385 hasConcept C188280979 @default.
• W2559942385 hasConcept C197754878 @default.
• W2559942385 hasConcept C203014093 @default.
• W2559942385 hasConcept C2522874641 @default.
• W2559942385 hasConcept C2779690655 @default.
• W2559942385 hasConcept C2780727368 @default.
• W2559942385 hasConcept C2908647359 @default.
• W2559942385 hasConcept C49105822 @default.
• W2559942385 hasConcept C54355233 @default.
• W2559942385 hasConcept C5911399 @default.
• W2559942385 hasConcept C71924100 @default.
• W2559942385 hasConcept C86803240 @default.
• W2559942385 hasConcept C99454951 @default.

• next