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- W2559953844 abstract "This is a retrospective cohort study of patients with a central giant cell granuloma (CGCG) treated at a single center to assess and compare the different surgical and non-surgical approaches. A cohort with a single histologically proven non-syndrome-related CGCG was selected and reviewed. Patients were allocated to group I (surgery), group II (pharmacotherapy), and group III (pharmacotherapy and surgery). The primary outcome was long-term radiologic response using computed tomography. Secondary outcomes were intermediate radiologic responses and occurrence and severity of side effects. Thirty-three subjects were included in the study. The surgical group (n = 4) included 1 patient with progression during follow-up and a relatively high post-surgical morbidity. Twenty-nine patients started on various pharmacological treatment regimens (groups II and III). Fourteen patients could be managed without additional surgery. One of these lesions showed progression during follow-up. The other 15 lesions underwent additional surgery, and none showed progression during follow-up. Interferon treatment was associated with the most side effects. Pharmacological agents have a role in the treatment of aggressive and non-aggressive CGCGs by limiting the renewed progression during long-term follow up and the extent and morbidity of surgical treatment." @default.
- W2559953844 created "2016-12-16" @default.
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- W2559953844 date "2017-02-01" @default.
- W2559953844 modified "2023-10-13" @default.
- W2559953844 title "Pharmacological and surgical therapy for the central giant cell granuloma: A long-term retrospective cohort study" @default.
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- W2559953844 doi "https://doi.org/10.1016/j.jcms.2016.11.011" @default.
- W2559953844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28087284" @default.
- W2559953844 hasPublicationYear "2017" @default.
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