FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559956750> ?p ?o ?g. }

• W2559956750 abstract "Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PAMany cancer therapies are intended to induce cell death within a target tumour. A substantial body of research using in vitro and in vivo models has demonstrated that cell death can be detected via quantitative ultrasound techniques. This study investigated the potential to quantify tumour responses to therapy in patients, using quantitative spectral and textural biomarkers extracted from low-frequency ultrasound data (4-10 MHz). Results demonstrate for the first time in a large cohort of patients the ability to predict clinical responders from non-responders as early as one week after the start of chemotherapy with over 95% sensitivity and 95% specificity.A clinical study was undertaken investigating the efficacy of ultrasound to quantify cell death in tumor responses with cancer treatment. Patients (n = 100) with locally advanced breast cancer received anthracyline and taxane-based chemotherapy treatments over four to six months. Data collection consisted of acquiring tumor images and radiofrequency data prior to treatment onset and at 4 times during neoadjuvant chemotherapy (weeks 0, 1, 4, 8 and pre-operatively). Data collection was carried out using an Ultrasonix-RP and an L15-5 6cm transducer pulsed at frequencies of ∼5 and ∼7 MHz, respectively. The majority of patients went on to have a modified radical mastectomy and correlative whole mount histopathology.Results obtained from both ∼5 and ∼7 MHz data indicated considerable increases in ultrasound spectral backscatter power in patients who clinically responded to treatment within one week of starting their chemotherapy. This was accompanied by significant increases in quantitative ultrasound spectral parameters such as mid-band-fit (up to 9.1 ± 1.2 dBr) and 0-MHz intercept (up to 10.8 ± 2.4 dBr). Patients categorized as poor responders clinically demonstrated significantly lower increases (1.9 ± 1.1 dBr and 1.4 ± 2.7 dBr for mid-band-fit and 0-MHz intercept, respectively). Textural biomarkers extracted from quantitative ultrasound spectral parametric maps also demonstrated considerable differences in trend between treatment responding and non-responding patients early after the treatment initiation.Statistically significant differences were found between treatment responding and non-responding patient populations using quantitative ultrasound spectral biomarkers 4 and 8 weeks after treatment initiation. Applying quantitative ultrasound textural biomarkers in order to incorporate response heterogeneities resulted in statistically significant differences between these two populations only one week after the start of chemotherapy. There were also associated survival differences between the two groups of patients. Patients with ultrasound-detected responses at week 1 had an over 90+/-5% 3 year survival whereas patients with no ultrasound-detected response at the same time had a 30+/10% survival (p<0.05).This study demonstrates the potential of ultrasound to quantify changes in tumours in response to cancer treatment administration in a clinical setting. The results indicate that such responses can be detected early during a course of chemotherapy. This can potentially permit ineffective treatments to be changed to more efficacious ones potentially leading to improved treatment outcomes within a framework of personalized medicine.Citation Format: Gregory Jan Czarnota, Ali Sadeghi-Naini, Hadi Tadayyon, Lakshmanan Sannachi, Mehrdad Gangeh, William Tran, Frances Wright, Sonal Gandhi, Kathleen Pritchard, Sunil Verma, Maureen Trudeau. Quantitative ultrasound for personalized chemotherapy in locally advanced breast cancer: Clinical trial results. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr CT317. doi:10.1158/1538-7445.AM2015-CT317" @default.
• W2559956750 created "2016-12-16" @default.
• W2559956750 creator A5010501409 @default.
• W2559956750 creator A5017745259 @default.
• W2559956750 creator A5030239845 @default.
• W2559956750 creator A5031884787 @default.
• W2559956750 creator A5039283573 @default.
• W2559956750 creator A5044517600 @default.
• W2559956750 creator A5046221783 @default.
• W2559956750 creator A5046342721 @default.
• W2559956750 creator A5047113165 @default.
• W2559956750 creator A5049907389 @default.
• W2559956750 creator A5068273693 @default.
• W2559956750 date "2015-08-01" @default.
• W2559956750 modified "2023-10-12" @default.
• W2559956750 title "Abstract CT317: Quantitative ultrasound for personalized chemotherapy in locally advanced breast cancer: Clinical trial results" @default.
• W2559956750 doi "https://doi.org/10.1158/1538-7445.am2015-ct317" @default.
• W2559956750 hasPublicationYear "2015" @default.
• W2559956750 type Work @default.
• W2559956750 sameAs 2559956750 @default.
• W2559956750 citedByCount "0" @default.
• W2559956750 crossrefType "proceedings-article" @default.
• W2559956750 hasAuthorship W2559956750A5010501409 @default.
• W2559956750 hasAuthorship W2559956750A5017745259 @default.
• W2559956750 hasAuthorship W2559956750A5030239845 @default.
• W2559956750 hasAuthorship W2559956750A5031884787 @default.
• W2559956750 hasAuthorship W2559956750A5039283573 @default.
• W2559956750 hasAuthorship W2559956750A5044517600 @default.
• W2559956750 hasAuthorship W2559956750A5046221783 @default.
• W2559956750 hasAuthorship W2559956750A5046342721 @default.
• W2559956750 hasAuthorship W2559956750A5047113165 @default.
• W2559956750 hasAuthorship W2559956750A5049907389 @default.
• W2559956750 hasAuthorship W2559956750A5068273693 @default.
• W2559956750 hasConcept C121608353 @default.
• W2559956750 hasConcept C126322002 @default.
• W2559956750 hasConcept C126838900 @default.
• W2559956750 hasConcept C142724271 @default.
• W2559956750 hasConcept C143753070 @default.
• W2559956750 hasConcept C143998085 @default.
• W2559956750 hasConcept C2776694085 @default.
• W2559956750 hasConcept C2777511904 @default.
• W2559956750 hasConcept C530470458 @default.
• W2559956750 hasConcept C535046627 @default.
• W2559956750 hasConcept C544855455 @default.
• W2559956750 hasConcept C71924100 @default.
• W2559956750 hasConceptScore W2559956750C121608353 @default.
• W2559956750 hasConceptScore W2559956750C126322002 @default.
• W2559956750 hasConceptScore W2559956750C126838900 @default.
• W2559956750 hasConceptScore W2559956750C142724271 @default.
• W2559956750 hasConceptScore W2559956750C143753070 @default.
• W2559956750 hasConceptScore W2559956750C143998085 @default.
• W2559956750 hasConceptScore W2559956750C2776694085 @default.
• W2559956750 hasConceptScore W2559956750C2777511904 @default.
• W2559956750 hasConceptScore W2559956750C530470458 @default.
• W2559956750 hasConceptScore W2559956750C535046627 @default.
• W2559956750 hasConceptScore W2559956750C544855455 @default.
• W2559956750 hasConceptScore W2559956750C71924100 @default.
• W2559956750 hasLocation W25599567501 @default.
• W2559956750 hasOpenAccess W2559956750 @default.
• W2559956750 hasPrimaryLocation W25599567501 @default.
• W2559956750 hasRelatedWork W1819767889 @default.
• W2559956750 hasRelatedWork W1968491338 @default.
• W2559956750 hasRelatedWork W1988255050 @default.
• W2559956750 hasRelatedWork W2004069148 @default.
• W2559956750 hasRelatedWork W2009934402 @default.
• W2559956750 hasRelatedWork W2031936372 @default.
• W2559956750 hasRelatedWork W2066718354 @default.
• W2559956750 hasRelatedWork W2090048990 @default.
• W2559956750 hasRelatedWork W2100884637 @default.
• W2559956750 hasRelatedWork W2109762309 @default.
• W2559956750 hasRelatedWork W2131741352 @default.
• W2559956750 hasRelatedWork W2290055860 @default.
• W2559956750 hasRelatedWork W2385045444 @default.
• W2559956750 hasRelatedWork W2519293369 @default.
• W2559956750 hasRelatedWork W2547679540 @default.
• W2559956750 hasRelatedWork W2625513944 @default.
• W2559956750 hasRelatedWork W2902698030 @default.
• W2559956750 hasRelatedWork W2985528026 @default.
• W2559956750 hasRelatedWork W3032723816 @default.
• W2559956750 hasRelatedWork W2733419693 @default.
• W2559956750 isParatext "false" @default.
• W2559956750 isRetracted "false" @default.
• W2559956750 magId "2559956750" @default.
• W2559956750 workType "article" @default.