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- W2559958855 abstract "The human EBV-transformed lymphoblastoid cell line (LCL), obtained by infecting peripheral blood monocular cells with Epstein–Barr Virus, has been extensively used for human genetic, pharmacogenomic, and immunologic studies. Recently, the role of exosomes has also been indicated as crucial in the crosstalk between EBV and the host microenvironment. Because the role that the LCL and LCL exosomal cargo might play in maintaining persistent infection, and since little is known regarding the non-coding RNAs of LCL, the aim of our work was the comprehensive characterization of this class of RNA, cellular and viral miRNAs, and cellular lncRNAs, in LCL compared with PBMC derived from the same donors. In this study, we have demonstrated, for the first time, that all the viral miRNAs expressed by LCL are also packaged in the exosomes, and we found that two miRNAs, ebv-miR-BART3 and ebv-miR-BHRF1-1, are more abundant in the exosomes, suggesting a microvescicular viral microRNA transfer. In addition, lncRNA profiling revealed that LCLs were enriched in lncRNA H19 and H19 antisense, and released these through exosomes, suggesting a leading role in the regulation of the tumor microenvironment." @default.
- W2559958855 created "2016-12-16" @default.
- W2559958855 creator A5010669543 @default.
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- W2559958855 creator A5039063139 @default.
- W2559958855 creator A5040056582 @default.
- W2559958855 creator A5050644274 @default.
- W2559958855 creator A5065450118 @default.
- W2559958855 creator A5072211896 @default.
- W2559958855 creator A5090817378 @default.
- W2559958855 date "2017-03-01" @default.
- W2559958855 modified "2023-09-23" @default.
- W2559958855 title "Global profiling of viral and cellular non-coding RNAs in Epstein–Barr virus-induced lymphoblastoid cell lines and released exosome cargos" @default.
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- W2559958855 doi "https://doi.org/10.1016/j.canlet.2016.12.003" @default.
- W2559958855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27956246" @default.