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- W2559964089 abstract "Genome-wide association studies have identified thousands of single nucleotide polymorphisms in the human genome that are statistically associated with particular disease traits. In this Perspective, we review emerging data suggesting that most single nucleotide polymorphisms associated with immune-mediated diseases are found in regulatory regions of the DNA – parts of the genome that control expression of the protein encoding genes – rather than causing mutations in proteins. We discuss how the emerging understanding of particular gene regulatory regions, gene enhancers and the epigenetic mechanisms by which they are regulated is opening up new opportunities for the treatment of immune-mediated diseases, focusing particularly on the BET family of epigenetic reader proteins as potential therapeutic targets." @default.
- W2559964089 created "2016-12-16" @default.
- W2559964089 creator A5029447427 @default.
- W2559964089 creator A5029672643 @default.
- W2559964089 date "2017-04-01" @default.
- W2559964089 modified "2023-10-13" @default.
- W2559964089 title "Immune disease-associated variants in gene enhancers point to BET epigenetic mechanisms for therapeutic intervention" @default.
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- W2559964089 cites W1580250799 @default.
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- W2559964089 cites W1971578941 @default.
- W2559964089 cites W1981030303 @default.
- W2559964089 cites W1981037015 @default.
- W2559964089 cites W1982085112 @default.
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- W2559964089 cites W1990174038 @default.
- W2559964089 cites W1992127633 @default.
- W2559964089 cites W1997453048 @default.
- W2559964089 cites W1998871958 @default.
- W2559964089 cites W2004966039 @default.
- W2559964089 cites W2008971261 @default.
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- W2559964089 cites W2034709147 @default.
- W2559964089 cites W2036619779 @default.
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- W2559964089 cites W2039594317 @default.
- W2559964089 cites W2043148368 @default.
- W2559964089 cites W2047412066 @default.
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- W2559964089 cites W2103393606 @default.
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- W2559964089 cites W2141171810 @default.
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- W2559964089 cites W2148934211 @default.
- W2559964089 cites W2150469988 @default.
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- W2559964089 cites W2153782423 @default.
- W2559964089 cites W2154746182 @default.
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- W2559964089 cites W2262384635 @default.
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- W2559964089 cites W2336446358 @default.
- W2559964089 cites W2339797972 @default.
- W2559964089 cites W2409937091 @default.
- W2559964089 cites W2422776163 @default.
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- W2559964089 doi "https://doi.org/10.2217/epi-2016-0144" @default.
- W2559964089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27925476" @default.
- W2559964089 hasPublicationYear "2017" @default.
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