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- W2559966155 abstract "The aim of the present study is to enhance the skin penetration and deposition of 8-methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8-MOP niosomes were prepared by the thin film hydration method using Span 60 or Span 40 along with cholesterol at five different molar ratios. The obtained vesicles revealed high entrapment efficiencies (83.04-89.90%) with nanometric vesicle diameters (111.1-198.8nm) of monodisperse distribution (PDI=0.145-0.216), zeta potential values <-48.3mV and spherical morphology under transmission electron microscopy. Optimized niosomal formulations depicted a biphasic in vitro release pattern in phosphate buffer (pH 5.5)/ethanol (7:3v/v) and displayed good physical stability after storage for 6 months at room (20-25°C) and refrigeration (4-8°C) temperatures. The two optimized formulations were incorporated in 5% sodium carboxy methylcellulose based hydrogel matrix which showed optimum pH values (7.37-7.39), pseudoplastic with thixotropic rheological behavior and more retarded 8-MOP release, by 23.82 and 14.89%, compared to niosomal vesicles after 24h. In vitro drug permeation and deposition studies, using rat skins, revealed promoted penetration and accumulation of 8-MOP after 8h. The skin penetration was further confirmed in vivo by confocal laser scanning microscopy, after 2h application period using rhodamine-loaded niosomal hydrogels compared to plain rhodamine hydrogel, as a florescence marker. Therefore, enhanced permeation and skin deposition of 8-MOP delivered by niosomes may help in improving the efficacy and safety of long-term treatment with 8-MOP." @default.
- W2559966155 created "2016-12-16" @default.
- W2559966155 creator A5012966519 @default.
- W2559966155 creator A5038618422 @default.
- W2559966155 creator A5048516410 @default.
- W2559966155 date "2017-01-01" @default.
- W2559966155 modified "2023-10-06" @default.
- W2559966155 title "Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition" @default.
- W2559966155 cites W1510388360 @default.
- W2559966155 cites W1526743142 @default.
- W2559966155 cites W1583962829 @default.
- W2559966155 cites W1804724315 @default.
- W2559966155 cites W1966337984 @default.
- W2559966155 cites W1970128839 @default.
- W2559966155 cites W1971133824 @default.
- W2559966155 cites W1972387325 @default.
- W2559966155 cites W1972452921 @default.
- W2559966155 cites W1974120683 @default.
- W2559966155 cites W1978675383 @default.
- W2559966155 cites W1981433605 @default.
- W2559966155 cites W1981636071 @default.
- W2559966155 cites W1984807766 @default.
- W2559966155 cites W1987659508 @default.
- W2559966155 cites W1988144726 @default.
- W2559966155 cites W1990098432 @default.
- W2559966155 cites W1990199698 @default.
- W2559966155 cites W1993897373 @default.
- W2559966155 cites W1994381824 @default.
- W2559966155 cites W2000734678 @default.
- W2559966155 cites W2003297681 @default.
- W2559966155 cites W2004647930 @default.
- W2559966155 cites W2007063916 @default.
- W2559966155 cites W2009300512 @default.
- W2559966155 cites W2011873005 @default.
- W2559966155 cites W2013500776 @default.
- W2559966155 cites W2014325374 @default.
- W2559966155 cites W2015382158 @default.
- W2559966155 cites W2017152124 @default.
- W2559966155 cites W2018785523 @default.
- W2559966155 cites W2021543425 @default.
- W2559966155 cites W2024599229 @default.
- W2559966155 cites W2026916418 @default.
- W2559966155 cites W2033026349 @default.
- W2559966155 cites W2033252275 @default.
- W2559966155 cites W2034659893 @default.
- W2559966155 cites W2036481603 @default.
- W2559966155 cites W2038153821 @default.
- W2559966155 cites W2041610629 @default.
- W2559966155 cites W2042253098 @default.
- W2559966155 cites W2045578160 @default.
- W2559966155 cites W2050656614 @default.
- W2559966155 cites W2052129346 @default.
- W2559966155 cites W2058204540 @default.
- W2559966155 cites W2060612529 @default.
- W2559966155 cites W2062767906 @default.
- W2559966155 cites W2063776447 @default.
- W2559966155 cites W2066432116 @default.
- W2559966155 cites W2068598019 @default.
- W2559966155 cites W2074718848 @default.
- W2559966155 cites W2075428301 @default.
- W2559966155 cites W2075706054 @default.
- W2559966155 cites W2075953443 @default.
- W2559966155 cites W2079025207 @default.
- W2559966155 cites W2080602020 @default.
- W2559966155 cites W2082573078 @default.
- W2559966155 cites W2091376303 @default.
- W2559966155 cites W2092105570 @default.
- W2559966155 cites W2092161257 @default.
- W2559966155 cites W2092222009 @default.
- W2559966155 cites W2094034721 @default.
- W2559966155 cites W2100459075 @default.
- W2559966155 cites W2102432127 @default.
- W2559966155 cites W2113039531 @default.
- W2559966155 cites W2118639164 @default.
- W2559966155 cites W2119299183 @default.
- W2559966155 cites W2119329430 @default.
- W2559966155 cites W2119364806 @default.
- W2559966155 cites W2128558503 @default.
- W2559966155 cites W2130218657 @default.
- W2559966155 cites W2132559847 @default.
- W2559966155 cites W2143298757 @default.
- W2559966155 cites W2161981769 @default.
- W2559966155 cites W2178869223 @default.
- W2559966155 cites W2184622055 @default.
- W2559966155 cites W2235674819 @default.
- W2559966155 cites W2326486821 @default.
- W2559966155 cites W2465710044 @default.
- W2559966155 cites W2484693293 @default.
- W2559966155 cites W2515639740 @default.
- W2559966155 cites W4235677912 @default.
- W2559966155 cites W77825061 @default.
- W2559966155 cites W950508456 @default.
- W2559966155 cites W1983279407 @default.
- W2559966155 doi "https://doi.org/10.1016/j.ijpharm.2016.12.018" @default.
- W2559966155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27956194" @default.
- W2559966155 hasPublicationYear "2017" @default.
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