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- W2559968135 abstract "To determine the influence of Smoc2 on hepatocellular carcinoma (HCC) cell proliferation and to find a possible new therapeutic target for preventing HCC progression.We detected expression of Smoc2 in HCC tissues and corresponding non-tumor liver (CNL) tissues using PCR, western blot, and immunohistochemistry methods. Subsequently, we down-regulated and up-regulated Smoc2 expression using siRNA and lentivirus transfection assay, respectively. Then, we identified the effect of Smoc2 on cell proliferation and cell cycle using CCK-8 and flow cytometry, respectively. The common cell growth signaling influenced by Smoc2 was detected by western blot assay.The expression of Smoc2 was significantly higher in HCC tissues compared with CNL tissues. Overexpression of Smoc2 promoted HCC cell proliferation and cell cycle progression. Down-regulation of Smoc2 led to inhibition of cell proliferation and cell cycle progression. Smoc2 had positive effect on ERK and AKT signaling.Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression and might act as an anti-cancer therapeutic target in the future." @default.
- W2559968135 created "2016-12-16" @default.
- W2559968135 creator A5064468525 @default.
- W2559968135 creator A5072056125 @default.
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- W2559968135 date "2016-01-01" @default.
- W2559968135 modified "2023-09-27" @default.
- W2559968135 title "Smoc2 potentiates proliferation of hepatocellular carcinoma cells <i>via</i> promotion of cell cycle progression" @default.
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- W2559968135 doi "https://doi.org/10.3748/wjg.v22.i45.10053" @default.
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