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- W2559968222 abstract "Herbal medicine preparations from medicinal plants to treat malaria are potential source of new anti-malarial drug development. The objective of this study was to evaluate antiplasmodial activity of fractions and sub fractions of the ethanol extract of Clerodendrum myricoides leaves using 4-day suppressive test against Plasmodium berghei in Swiss albino mice. Methanol fraction (MF) and ethyl acetate fraction (EF) obtained from the successive fractionation of ethanol crude extract of C. myricoides showed highest activity with suppression of 77.24% and 65.21% at an oral dose of 300 mg/kg/day respectively. Further, bioactivity guided fractionation (BGF) of ethanol extract provided some fractions which exhibited good antiplasmodial activity. From these, Hexane sub fraction (Hsf) was the most active that induced suppression of parasitaemia by 40.34% and 46.56% at 50 mg/kg and 100 mg/kg doses respectively. Hsf chromatographic sub fractions also induced suppression of parasitaemia by 45.89 and 50.53% at 20 mg/kg and 40 mg/kg of Hsf-5, respectively, and by 38.61 and 44.12% at 20 mg/kg and 40 mg/kg of Hsf-14, respectively. Bioactivity guided fractionation resulted in loss of antiplasmodial activity of the fractions and sub fractions and this leads to the conclusion that the activity of the plant leaves was due to synergistic effect of many active compounds" @default.
- W2559968222 created "2016-12-16" @default.
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- W2559968222 date "2016-01-01" @default.
- W2559968222 modified "2023-09-25" @default.
- W2559968222 title "In Vivo Antiplasmodial Activity of Fractions and Chromatographic Sub Fractionions of Ethanol Extract of <i>Clerodendrum Myricoides</i> Leaves" @default.
- W2559968222 doi "https://doi.org/10.11648/j.jddmc.20160206.11" @default.
- W2559968222 hasPublicationYear "2016" @default.
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