Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560005082> ?p ?o ?g. }
- W2560005082 abstract "Alzheimer's disease (AD) transgenic mice have been used as a standard AD model for basic mechanistic studies and drug discovery. These mouse models showed symbolic AD pathologies including β-amyloid (Aβ) plaques, gliosis and memory deficits but failed to fully recapitulate AD pathogenic cascades including robust phospho tau (p-tau) accumulation, clear neurofibrillary tangles (NFTs) and neurodegeneration, solely driven by familial AD (FAD) mutation(s). Recent advances in human stem cell and three-dimensional (3D) culture technologies made it possible to generate novel 3D neural cell culture models that recapitulate AD pathologies including robust Aβ deposition and Aβ-driven NFT-like tau pathology. These new 3D human cell culture models of AD hold a promise for a novel platform that can be used for mechanism studies in human brain-like environment and high-throughput drug screening (HTS). In this review, we will summarize the current progress in recapitulating AD pathogenic cascades in human neural cell culture models using AD patient-derived induced pluripotent stem cells (iPSCs) or genetically modified human stem cell lines. We will also explain how new 3D culture technologies were applied to accelerate Aβ and p-tau pathologies in human neural cell cultures, as compared the standard two-dimensional (2D) culture conditions. Finally, we will discuss a potential impact of the human 3D human neural cell culture models on the AD drug-development process. These revolutionary 3D culture models of AD will contribute to accelerate the discovery of novel AD drugs." @default.
- W2560005082 created "2016-12-16" @default.
- W2560005082 creator A5020918785 @default.
- W2560005082 creator A5050004777 @default.
- W2560005082 creator A5059046547 @default.
- W2560005082 creator A5084656376 @default.
- W2560005082 creator A5089342007 @default.
- W2560005082 date "2016-12-01" @default.
- W2560005082 modified "2023-10-17" @default.
- W2560005082 title "3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”" @default.
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