FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560024581> ?p ?o ?g. }

• W2560024581 endingPage "e2513" @default.
• W2560024581 startingPage "e2513" @default.
• W2560024581 abstract "Abstract Hyperhomocysteinemia (HHcy) is a well-known risk factor for stroke; however, its underlying molecular mechanism remains unclear. Using both mouse and cell culture models, we have provided evidence that impairment of autophagy has a central role in HHcy-induced cellular injury in the mouse brain. We observed accumulation of LC3B-II and p62 that was associated with increased MTOR signaling in human and mouse primary astrocyte cell cultures as well as a diet-induced mouse model of HHcy, HHcy decreased lysosomal membrane protein LAMP2, vacuolar ATPase (ATP6V0A2), and protease cathepsin D, suggesting that lysosomal dysfunction also contributed to the autophagic defect. Moreover, HHcy increased unfolded protein response. Interestingly, Vitamin B supplementation restored autophagic flux, alleviated ER stress, and reversed lysosomal dysfunction due to HHCy. Furthermore, the autophagy inducer, rapamycin was able to relieve ER stress and reverse lysosomal dysfunction caused by HHcy in vitro . Inhibition of autophagy by HHcy exacerbated cellular injury during oxygen and glucose deprivation and reperfusion (OGD/R), and oxidative stress. These effects were prevented by Vitamin B co-treatment, suggesting that it may be helpful in relieving detrimental effects of HHcy in ischemia/reperfusion or oxidative stress. Collectively, these findings show that Vitamin B therapy can reverse defects in cellular autophagy and ER stress due to HHcy; and thus may be a potential treatment to reduce ischemic damage caused by stroke in patients with HHcy." @default.
• W2560024581 created "2016-12-16" @default.
• W2560024581 creator A5015934115 @default.
• W2560024581 creator A5021858366 @default.
• W2560024581 creator A5039042118 @default.
• W2560024581 creator A5040378404 @default.
• W2560024581 creator A5069785686 @default.
• W2560024581 creator A5072207778 @default.
• W2560024581 creator A5091189572 @default.
• W2560024581 date "2016-12-08" @default.
• W2560024581 modified "2023-10-14" @default.
• W2560024581 title "Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation" @default.
• W2560024581 cites W1897351868 @default.
• W2560024581 cites W1959227492 @default.
• W2560024581 cites W1971486820 @default.
• W2560024581 cites W1973264103 @default.
• W2560024581 cites W1976531450 @default.
• W2560024581 cites W1985394365 @default.
• W2560024581 cites W1987431150 @default.
• W2560024581 cites W1993824787 @default.
• W2560024581 cites W1998319919 @default.
• W2560024581 cites W2003899957 @default.
• W2560024581 cites W2006084919 @default.
• W2560024581 cites W2018788779 @default.
• W2560024581 cites W2024268760 @default.
• W2560024581 cites W2024578526 @default.
• W2560024581 cites W2024858284 @default.
• W2560024581 cites W2026066807 @default.
• W2560024581 cites W2038291983 @default.
• W2560024581 cites W2043718270 @default.
• W2560024581 cites W2050547186 @default.
• W2560024581 cites W2062378136 @default.
• W2560024581 cites W2063403801 @default.
• W2560024581 cites W2066280893 @default.
• W2560024581 cites W2069120762 @default.
• W2560024581 cites W2076683315 @default.
• W2560024581 cites W2077798795 @default.
• W2560024581 cites W2090014647 @default.
• W2560024581 cites W2104119228 @default.
• W2560024581 cites W2117166284 @default.
• W2560024581 cites W2127916470 @default.
• W2560024581 cites W2132780908 @default.
• W2560024581 cites W2139948451 @default.
• W2560024581 cites W2150158558 @default.
• W2560024581 cites W2153188271 @default.
• W2560024581 cites W2153648772 @default.
• W2560024581 cites W2153998249 @default.
• W2560024581 cites W2164778558 @default.
• W2560024581 cites W2168453644 @default.
• W2560024581 cites W2401296772 @default.
• W2560024581 cites W770046287 @default.
• W2560024581 doi "https://doi.org/10.1038/cddis.2016.374" @default.
• W2560024581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5260994" @default.
• W2560024581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27929536" @default.
• W2560024581 hasPublicationYear "2016" @default.
• W2560024581 type Work @default.
• W2560024581 sameAs 2560024581 @default.
• W2560024581 citedByCount "47" @default.
• W2560024581 countsByYear W25600245812017 @default.
• W2560024581 countsByYear W25600245812018 @default.
• W2560024581 countsByYear W25600245812019 @default.
• W2560024581 countsByYear W25600245812020 @default.
• W2560024581 countsByYear W25600245812021 @default.
• W2560024581 countsByYear W25600245812022 @default.
• W2560024581 countsByYear W25600245812023 @default.
• W2560024581 crossrefType "journal-article" @default.
• W2560024581 hasAuthorship W2560024581A5015934115 @default.
• W2560024581 hasAuthorship W2560024581A5021858366 @default.
• W2560024581 hasAuthorship W2560024581A5039042118 @default.
• W2560024581 hasAuthorship W2560024581A5040378404 @default.
• W2560024581 hasAuthorship W2560024581A5069785686 @default.
• W2560024581 hasAuthorship W2560024581A5072207778 @default.
• W2560024581 hasAuthorship W2560024581A5091189572 @default.
• W2560024581 hasBestOaLocation W25600245811 @default.
• W2560024581 hasConcept C126322002 @default.
• W2560024581 hasConcept C134018914 @default.
• W2560024581 hasConcept C139447449 @default.
• W2560024581 hasConcept C158617107 @default.
• W2560024581 hasConcept C181199279 @default.
• W2560024581 hasConcept C190283241 @default.
• W2560024581 hasConcept C203522944 @default.
• W2560024581 hasConcept C2776151105 @default.
• W2560024581 hasConcept C2776523773 @default.
• W2560024581 hasConcept C2777090595 @default.
• W2560024581 hasConcept C2780216420 @default.
• W2560024581 hasConcept C28021979 @default.
• W2560024581 hasConcept C31573885 @default.
• W2560024581 hasConcept C55493867 @default.
• W2560024581 hasConcept C71924100 @default.
• W2560024581 hasConcept C86803240 @default.
• W2560024581 hasConcept C95444343 @default.
• W2560024581 hasConceptScore W2560024581C126322002 @default.
• W2560024581 hasConceptScore W2560024581C134018914 @default.
• W2560024581 hasConceptScore W2560024581C139447449 @default.
• W2560024581 hasConceptScore W2560024581C158617107 @default.
• W2560024581 hasConceptScore W2560024581C181199279 @default.
• W2560024581 hasConceptScore W2560024581C190283241 @default.
• W2560024581 hasConceptScore W2560024581C203522944 @default.

• next