FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560041020> ?p ?o ?g. }

• W2560041020 abstract "Many of the posttraumatic stress disorder (PTSD) treatment guidelines recognize the use of selective serotonin reuptake inhibitors as first-line pharmacological treatment. In Japan, there were no published studies investigating the effectiveness and safety of sertraline for PTSD in a clinical setting.We conducted a retrospective medical chart review of the dosage, effectiveness, and safety of sertraline for the PTSD treatment in Japan. Data were collected from medical charts of patients of PTSD, caused by various types of trauma, who were treated with sertraline between July 2006 and October 2012 during their regular clinical practice. To evaluate the effectiveness, the investigators retrospectively assessed the severity and improvement of the symptoms using the Clinical Global Impressions - Severity and the Clinical Global Impressions - Improvement.The study population was 122 Japanese patients aged ≥18 years with a diagnosis of PTSD who were treated with sertraline (median duration, 10.6 months). Doses ranged from 12.5 to 150 mg/day, mostly 25 and 50 mg/day. The median duration of observation was 10.8 months. Out of those, 50% of patients were regarded as responders by using the Clinical Global Impressions - Improvement at the end of sertraline treatment or the last observation. Two-thirds (65.6%) of patients improved in the severity of PTSD, as assessed by Clinical Global Impressions - Severity, whereas 32.8% showed no change, and 1.6% worsened. Subgroups analyses and logistic regression analyses suggested that the type of traumatic events was the factor with the highest influence on the response rate. The adverse events in this chart review were consistent with the known safety profile of sertraline. There were no reports of serious or severe adverse events considered to be related to sertraline.Our study suggested the effectiveness of sertraline for the treatment of PTSD in a Japanese clinical setting, and the obtained safety profile was consistent with the generally known safety profile of sertraline.ClinicalTrials.gov (Identification No. NCT01607593 ). Registered May 21, 2012." @default.
• W2560041020 created "2016-12-16" @default.
• W2560041020 creator A5023195671 @default.
• W2560041020 creator A5035322614 @default.
• W2560041020 creator A5036454236 @default.
• W2560041020 creator A5037306798 @default.
• W2560041020 creator A5064565558 @default.
• W2560041020 creator A5079268987 @default.
• W2560041020 creator A5088788720 @default.
• W2560041020 date "2016-12-01" @default.
• W2560041020 modified "2023-10-16" @default.
• W2560041020 title "Dosage, effectiveness, and safety of sertraline treatment for posttraumatic stress disorder in a Japanese clinical setting: a retrospective study" @default.
• W2560041020 cites W1489641999 @default.
• W2560041020 cites W1511020442 @default.
• W2560041020 cites W1989253089 @default.
• W2560041020 cites W2003662114 @default.
• W2560041020 cites W2039284835 @default.
• W2560041020 cites W2040626393 @default.
• W2560041020 cites W2088782944 @default.
• W2560041020 cites W2090432427 @default.
• W2560041020 cites W2102215436 @default.
• W2560041020 cites W2102454290 @default.
• W2560041020 cites W2114214919 @default.
• W2560041020 cites W2118542639 @default.
• W2560041020 cites W2124867538 @default.
• W2560041020 cites W2139206480 @default.
• W2560041020 cites W2139641449 @default.
• W2560041020 cites W2160157454 @default.
• W2560041020 cites W2165415246 @default.
• W2560041020 cites W4247665917 @default.
• W2560041020 cites W4255396331 @default.
• W2560041020 doi "https://doi.org/10.1186/s12888-016-1138-5" @default.
• W2560041020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5142275" @default.
• W2560041020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27923359" @default.
• W2560041020 hasPublicationYear "2016" @default.
• W2560041020 type Work @default.
• W2560041020 sameAs 2560041020 @default.
• W2560041020 citedByCount "5" @default.
• W2560041020 countsByYear W25600410202018 @default.
• W2560041020 countsByYear W25600410202019 @default.
• W2560041020 countsByYear W25600410202022 @default.
• W2560041020 crossrefType "journal-article" @default.
• W2560041020 hasAuthorship W2560041020A5023195671 @default.
• W2560041020 hasAuthorship W2560041020A5035322614 @default.
• W2560041020 hasAuthorship W2560041020A5036454236 @default.
• W2560041020 hasAuthorship W2560041020A5037306798 @default.
• W2560041020 hasAuthorship W2560041020A5064565558 @default.
• W2560041020 hasAuthorship W2560041020A5079268987 @default.
• W2560041020 hasAuthorship W2560041020A5088788720 @default.
• W2560041020 hasBestOaLocation W25600410201 @default.
• W2560041020 hasConcept C118552586 @default.
• W2560041020 hasConcept C126322002 @default.
• W2560041020 hasConcept C151956035 @default.
• W2560041020 hasConcept C167135981 @default.
• W2560041020 hasConcept C197934379 @default.
• W2560041020 hasConcept C2777669559 @default.
• W2560041020 hasConcept C2779177272 @default.
• W2560041020 hasConcept C2780092697 @default.
• W2560041020 hasConcept C2908647359 @default.
• W2560041020 hasConcept C558461103 @default.
• W2560041020 hasConcept C71924100 @default.
• W2560041020 hasConcept C99454951 @default.
• W2560041020 hasConceptScore W2560041020C118552586 @default.
• W2560041020 hasConceptScore W2560041020C126322002 @default.
• W2560041020 hasConceptScore W2560041020C151956035 @default.
• W2560041020 hasConceptScore W2560041020C167135981 @default.
• W2560041020 hasConceptScore W2560041020C197934379 @default.
• W2560041020 hasConceptScore W2560041020C2777669559 @default.
• W2560041020 hasConceptScore W2560041020C2779177272 @default.
• W2560041020 hasConceptScore W2560041020C2780092697 @default.
• W2560041020 hasConceptScore W2560041020C2908647359 @default.
• W2560041020 hasConceptScore W2560041020C558461103 @default.
• W2560041020 hasConceptScore W2560041020C71924100 @default.
• W2560041020 hasConceptScore W2560041020C99454951 @default.
• W2560041020 hasIssue "1" @default.
• W2560041020 hasLocation W25600410201 @default.
• W2560041020 hasLocation W25600410202 @default.
• W2560041020 hasLocation W25600410203 @default.
• W2560041020 hasLocation W25600410204 @default.
• W2560041020 hasOpenAccess W2560041020 @default.
• W2560041020 hasPrimaryLocation W25600410201 @default.
• W2560041020 hasRelatedWork W1530061410 @default.
• W2560041020 hasRelatedWork W1966381163 @default.
• W2560041020 hasRelatedWork W2034112753 @default.
• W2560041020 hasRelatedWork W2078641702 @default.
• W2560041020 hasRelatedWork W2094394606 @default.
• W2560041020 hasRelatedWork W2131406097 @default.
• W2560041020 hasRelatedWork W2171426021 @default.
• W2560041020 hasRelatedWork W2510701701 @default.
• W2560041020 hasRelatedWork W2625005961 @default.
• W2560041020 hasRelatedWork W3030361958 @default.
• W2560041020 hasVolume "16" @default.
• W2560041020 isParatext "false" @default.
• W2560041020 isRetracted "false" @default.
• W2560041020 magId "2560041020" @default.
• W2560041020 workType "article" @default.