FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560041938> ?p ?o ?g. }

• W2560041938 abstract "Gene expression is a noisy process that leads to regime shift between alternative steady states among individual living cells, inducing phenotypic variability. The effects of white noise on the regime shift in bistable systems have been well characterized, however little is known about such effects of colored noise (noise with non-zero correlation time). Here, we show that noise correlation time, by considering a genetic circuit of autoactivation, can have significant effect on the regime shift in gene expression. We demonstrate this theoretically, using stochastic potential, stationary probability density function and first-passage time based on the Fokker-Planck description, where the Ornstein-Uhlenbeck process is used to model colored noise. We find that increase in noise correlation time in degradation rate can induce a regime shift from low to high protein concentration state and enhance the bistable regime, while increase in noise correlation time in basal rate retain the bimodal distribution. We then show how cross-correlated colored noises in basal and degradation rates can induce regime shifts from low to high protein concentration state, but reduce the bistable regime. In addition, we show that early warning indicators can also be used to predict shifts between distinct phenotypic states in gene expression. Predictions that a cell is about to shift to a harmful phenotype could improve early therapeutic intervention in complex human diseases." @default.
• W2560041938 created "2016-12-16" @default.
• W2560041938 creator A5045289748 @default.
• W2560041938 creator A5066175720 @default.
• W2560041938 date "2017-08-18" @default.
• W2560041938 modified "2023-09-24" @default.
• W2560041938 title "Regime shifts driven by dynamic correlations in gene expression noise" @default.
• W2560041938 cites W1642251103 @default.
• W2560041938 cites W1966512215 @default.
• W2560041938 cites W1973890190 @default.
• W2560041938 cites W1974801008 @default.
• W2560041938 cites W1983577042 @default.
• W2560041938 cites W1985654700 @default.
• W2560041938 cites W1987862415 @default.
• W2560041938 cites W1999716743 @default.
• W2560041938 cites W2007614382 @default.
• W2560041938 cites W2011866841 @default.
• W2560041938 cites W2015584886 @default.
• W2560041938 cites W2016546231 @default.
• W2560041938 cites W2018435536 @default.
• W2560041938 cites W2025756337 @default.
• W2560041938 cites W2029315569 @default.
• W2560041938 cites W2032069681 @default.
• W2560041938 cites W2034331807 @default.
• W2560041938 cites W2035471593 @default.
• W2560041938 cites W2040565342 @default.
• W2560041938 cites W2045254026 @default.
• W2560041938 cites W2046451925 @default.
• W2560041938 cites W2050826226 @default.
• W2560041938 cites W2051304045 @default.
• W2560041938 cites W2053300556 @default.
• W2560041938 cites W2058224146 @default.
• W2560041938 cites W2064050252 @default.
• W2560041938 cites W2068967127 @default.
• W2560041938 cites W2073141004 @default.
• W2560041938 cites W2079769483 @default.
• W2560041938 cites W2081898212 @default.
• W2560041938 cites W2090063036 @default.
• W2560041938 cites W2091198609 @default.
• W2560041938 cites W2100106837 @default.
• W2560041938 cites W2103096980 @default.
• W2560041938 cites W2103948957 @default.
• W2560041938 cites W2105057212 @default.
• W2560041938 cites W2106362845 @default.
• W2560041938 cites W2116199452 @default.
• W2560041938 cites W2120737414 @default.
• W2560041938 cites W2122219241 @default.
• W2560041938 cites W2126733261 @default.
• W2560041938 cites W2127968216 @default.
• W2560041938 cites W2128573963 @default.
• W2560041938 cites W2135264057 @default.
• W2560041938 cites W2136390898 @default.
• W2560041938 cites W2143222716 @default.
• W2560041938 cites W2145137020 @default.
• W2560041938 cites W2152223517 @default.
• W2560041938 cites W2153268540 @default.
• W2560041938 cites W2163680029 @default.
• W2560041938 cites W2221245628 @default.
• W2560041938 cites W2316717691 @default.
• W2560041938 cites W2536132766 @default.
• W2560041938 cites W3101146854 @default.
• W2560041938 cites W4299870202 @default.
• W2560041938 cites W2027846595 @default.
• W2560041938 doi "https://doi.org/10.1103/physreve.96.022409" @default.
• W2560041938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28950646" @default.
• W2560041938 hasPublicationYear "2017" @default.
• W2560041938 type Work @default.
• W2560041938 sameAs 2560041938 @default.
• W2560041938 citedByCount "7" @default.
• W2560041938 countsByYear W25600419382018 @default.
• W2560041938 countsByYear W25600419382019 @default.
• W2560041938 countsByYear W25600419382020 @default.
• W2560041938 countsByYear W25600419382021 @default.
• W2560041938 countsByYear W25600419382022 @default.
• W2560041938 crossrefType "journal-article" @default.
• W2560041938 hasAuthorship W2560041938A5045289748 @default.
• W2560041938 hasAuthorship W2560041938A5066175720 @default.
• W2560041938 hasBestOaLocation W25600419382 @default.
• W2560041938 hasConcept C105795698 @default.
• W2560041938 hasConcept C112633086 @default.
• W2560041938 hasConcept C114996537 @default.
• W2560041938 hasConcept C115961682 @default.
• W2560041938 hasConcept C121332964 @default.
• W2560041938 hasConcept C121864883 @default.
• W2560041938 hasConcept C133386390 @default.
• W2560041938 hasConcept C154945302 @default.
• W2560041938 hasConcept C186659197 @default.
• W2560041938 hasConcept C207658827 @default.
• W2560041938 hasConcept C33923547 @default.
• W2560041938 hasConcept C41008148 @default.
• W2560041938 hasConcept C53622274 @default.
• W2560041938 hasConcept C62520636 @default.
• W2560041938 hasConcept C97292510 @default.
• W2560041938 hasConcept C99498987 @default.
• W2560041938 hasConceptScore W2560041938C105795698 @default.
• W2560041938 hasConceptScore W2560041938C112633086 @default.
• W2560041938 hasConceptScore W2560041938C114996537 @default.
• W2560041938 hasConceptScore W2560041938C115961682 @default.
• W2560041938 hasConceptScore W2560041938C121332964 @default.
• W2560041938 hasConceptScore W2560041938C121864883 @default.

• next