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• W2560096114 abstract "Vasospastic angina (VSA) can result in endothelial damage and thrombus formation. The aim of this study was to evaluate the incidence of thrombus and plaque characteristics at coronary spasm segments compared with nonspasm segments by using optical coherence tomography (OCT) in patients with suspected VSA. One hundred and eighty-three patients with suspected VSA were enrolled in this study. The ergonovine provocation test was performed in all patients for the diagnosis of VSA except in patients with spontaneous spasm. All target lesions were analyzed by OCT. Plaque erosion was defined as the presence of attached thrombus overlying an intact fibrous cap and visualized plaque on multiple adjacent OCT frames. One hundred and nine spasm segments (93 patients) were compared with 55 nonspasm segments (39 patients). Thrombus was more frequently seen at spasm segments than at nonspasm segments (28.4% vs 7.3%; P = .026) and thrombus size was larger at spasm segments than at nonspasm segments (0.26 ± 0.50 mm2 vs 0.04 ± 0.01 mm2; P = .023). Thin-cap fibroatheroma was more frequently seen at nonspasm segments than at spasm segments (16.4% vs 1.8%; P = .006). Plaque erosion was more prevalent at spasm segments than at nonspasm segments (25.7% vs 5.4%; P = .001). Thrombus and plaque erosion were more common at spasm segments than at nonspasm segments assessed by OCT in patients with suspected VSA. These findings suggest the potential benefit and treatment role of antiplatelet therapy in vasospastic angina. La angina vasospástica (AVS) puede causar daño endotelial y formación de trombo. El objetivo de este estudio es evaluar mediante tomografía de coherencia óptica (OCT) la incidencia de trombo y las características de la placa en segmentos con espasmo coronario comparados con segmentos sin espasmo en pacientes con sospecha de AVS. Se incluyó a 183 pacientes con sospecha de AVS. Para el diagnóstico de AVS se realizó test de provocación con ergonovina en todos los pacientes, excepto aquellos con espasmo espontáneo. Se analizaron por OCT todas las lesiones diana. Se definió erosión de placa como la presencia de trombo adherido a una capa fibrosa intacta y visualizada en múltiples cortes de OCT. Se compararon 109 segmentos con espasmo (93 pacientes) con 55 segmentos sin espasmo (39 pacientes). Se observó una mayor incidencia de trombo en los segmentos con espasmo coronario que en los segmentos sin espasmo (el 28,4 frente al 7,3%; p = 0,026) y el tamaño del trombo fue mayor en los primeros que en los segundos (0,26 ± 0,50 frente a 0,04 ± 0,01 mm2; p = 0,023). Se observó ateroma de capa fina con mayor frecuencia en segmentos sin espasmo que en aquellos con espasmo (el 16,4 frente al 1,8%; p = 0,006). La erosión de la placa fue más prevalente en los segmentos con espasmo que en los segmentos sin espasmo (el 25,7 frente a 5,4%; p = 0,001). La presencia de trombo y erosión de placa analizados por OCT fue más frecuente en los segmentos con espasmo que en aquellos sin espasmo en pacientes con sospecha de AVS. Estos hallazgos apuntan a un potencial beneficio del tratamiento antiagregante para estos pacientes." @default.
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• W2560096114 date "2017-06-01" @default.
• W2560096114 modified "2023-10-16" @default.
• W2560096114 title "Thrombus and Plaque Erosion Characterized by Optical Coherence Tomography in Patients With Vasospastic Angina" @default.
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• W2560096114 doi "https://doi.org/10.1016/j.rec.2016.11.003" @default.
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