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- W2560105603 abstract "HIV-1 infection has been transformed by combined anti-retroviral therapy (ART), changing a universally fatal infection into a controllable infection. However, major obstacles for an HIV-1 cure exist. The HIV latent reservoir, which exists in resting CD4+ T cells, is not impacted by ART, and can reactivate when ART is interrupted or ceased. Additionally, multi-drug resistance can arise. One alternate approach to conventional HIV-1 drug treatment that is being explored involves gene therapies utilizing RNA-directed gene regulation. Commonly known as RNA interference (RNAi), short interfering RNA (siRNA) induce gene silencing in conserved biological pathways, which require a high degree of sequence specificity. This review will provide an overview of the silencing pathways, the current RNAi technologies being developed for HIV-1 gene therapy, current clinical trials, and the challenges faced in progressing these treatments into clinical trials." @default.
- W2560105603 created "2016-12-16" @default.
- W2560105603 creator A5010304528 @default.
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- W2560105603 creator A5041469251 @default.
- W2560105603 creator A5049499975 @default.
- W2560105603 creator A5075296673 @default.
- W2560105603 date "2016-12-07" @default.
- W2560105603 modified "2023-09-25" @default.
- W2560105603 title "Achieving HIV-1 Control through RNA-Directed Gene Regulation" @default.
- W2560105603 cites W1507403068 @default.
- W2560105603 cites W1598902601 @default.
- W2560105603 cites W1647075334 @default.
- W2560105603 cites W1832413898 @default.
- W2560105603 cites W185744503 @default.
- W2560105603 cites W1964146045 @default.
- W2560105603 cites W1966452674 @default.
- W2560105603 cites W1966858164 @default.
- W2560105603 cites W1970355156 @default.
- W2560105603 cites W1971112771 @default.
- W2560105603 cites W1971550264 @default.
- W2560105603 cites W1972637758 @default.
- W2560105603 cites W1973694997 @default.
- W2560105603 cites W1974488636 @default.
- W2560105603 cites W1974855063 @default.
- W2560105603 cites W1976840413 @default.
- W2560105603 cites W1978917197 @default.
- W2560105603 cites W1979389654 @default.
- W2560105603 cites W1979993551 @default.
- W2560105603 cites W1981607157 @default.
- W2560105603 cites W1981700062 @default.
- W2560105603 cites W1983361018 @default.
- W2560105603 cites W1986996414 @default.
- W2560105603 cites W1987962034 @default.
- W2560105603 cites W1989815284 @default.
- W2560105603 cites W1990377587 @default.
- W2560105603 cites W1993695454 @default.
- W2560105603 cites W1995953743 @default.
- W2560105603 cites W1999605403 @default.
- W2560105603 cites W2000906356 @default.
- W2560105603 cites W2003931886 @default.
- W2560105603 cites W2004040286 @default.
- W2560105603 cites W2006758510 @default.
- W2560105603 cites W2008718396 @default.
- W2560105603 cites W2010165685 @default.
- W2560105603 cites W2010605331 @default.
- W2560105603 cites W2010983260 @default.
- W2560105603 cites W2011208161 @default.
- W2560105603 cites W2011480379 @default.
- W2560105603 cites W2011569859 @default.
- W2560105603 cites W2011630381 @default.
- W2560105603 cites W2012607179 @default.
- W2560105603 cites W2014509855 @default.
- W2560105603 cites W2019851175 @default.
- W2560105603 cites W2031903610 @default.
- W2560105603 cites W2032381104 @default.
- W2560105603 cites W2034685489 @default.
- W2560105603 cites W2035813371 @default.
- W2560105603 cites W2037067282 @default.
- W2560105603 cites W2037854655 @default.
- W2560105603 cites W2038598840 @default.
- W2560105603 cites W2040234712 @default.
- W2560105603 cites W2041709256 @default.
- W2560105603 cites W2041867451 @default.
- W2560105603 cites W2043167746 @default.
- W2560105603 cites W2047385553 @default.
- W2560105603 cites W2049260812 @default.
- W2560105603 cites W2049490177 @default.
- W2560105603 cites W2055142955 @default.
- W2560105603 cites W2055796578 @default.
- W2560105603 cites W2057041879 @default.
- W2560105603 cites W2060221489 @default.
- W2560105603 cites W2061143375 @default.
- W2560105603 cites W2061432075 @default.
- W2560105603 cites W2063424967 @default.
- W2560105603 cites W2064614508 @default.
- W2560105603 cites W2068271334 @default.
- W2560105603 cites W2069904748 @default.
- W2560105603 cites W2072958095 @default.
- W2560105603 cites W2074161384 @default.
- W2560105603 cites W2074773259 @default.
- W2560105603 cites W2076011658 @default.
- W2560105603 cites W2077088013 @default.
- W2560105603 cites W2082371015 @default.
- W2560105603 cites W2085352570 @default.
- W2560105603 cites W2085384576 @default.
- W2560105603 cites W2086014879 @default.
- W2560105603 cites W2086227770 @default.
- W2560105603 cites W2090646713 @default.
- W2560105603 cites W2091288903 @default.
- W2560105603 cites W2091524919 @default.
- W2560105603 cites W2094146325 @default.
- W2560105603 cites W2095388109 @default.
- W2560105603 cites W2095570051 @default.
- W2560105603 cites W2098192588 @default.