Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560114628> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2560114628 abstract "CYLD is a negative regulator of NF-κB activity, yet in mice a short splice variant lacking exons 7 and 8 (or short CYLD (CYLD S )) with activating properties has also been described. In the present study we analyze the T cell-specific role of CYLD S in vitro and in vivo in a model of allergic airway disease. In addition we investigated if an equivalent is also expressed in humans. Using T cells derived from animals with a T cell specific expression of CYLD S we demonstrate that under Th9-polarizing conditions the production of IL-9 was enhanced, whereas under Th2-polarizing conditions production of IL-4 was not affected, compared to wild type (WT) cells. In contrast to WT animals, CyldFL*CD4cre animals developed an exacerbated asthma phenotype. Treatment with a neutralizing α-IL9 antibody during the challenge phase attenuates the asthma phenotype in CyldFL*CD4cre animals, but not in WT animals. By generation of specific primers we could demonstrate that humans express an undescribed splice variant of CYLD, lacking, as the mouse equivalent, the NEMO binding side. Activation of PBMC shifts the ratio of the full length CYLD (CYLD FL ) to CYLD S . Moreover, in comparison to healthy subjects asthmatics demonstrate by raising expression of CYLD FL a comparatively stronger expression of CYLD S . CYLD is an important regulator of NF-κB, driving the development of allergic airway disease by an IL-9 dependent pathway. Also a human homolog was discovered which was differently regulated in patients with asthma compared to healthy persons. Therefore, differential expression of CYLD splice variants could be an important determinant for the development of allergic airway disease." @default.
- W2560114628 created "2016-12-16" @default.
- W2560114628 creator A5025746046 @default.
- W2560114628 creator A5039376421 @default.
- W2560114628 creator A5039635841 @default.
- W2560114628 creator A5040230220 @default.
- W2560114628 creator A5053832875 @default.
- W2560114628 creator A5062987438 @default.
- W2560114628 creator A5074197659 @default.
- W2560114628 date "2015-09-01" @default.
- W2560114628 modified "2023-09-24" @default.
- W2560114628 title "A short splice variant of the tumor suppressor gene CYLD induces allergic airway disease in mice and is also expressed in humans" @default.
- W2560114628 doi "https://doi.org/10.1183/13993003.congress-2015.oa2003" @default.
- W2560114628 hasPublicationYear "2015" @default.
- W2560114628 type Work @default.
- W2560114628 sameAs 2560114628 @default.
- W2560114628 citedByCount "0" @default.
- W2560114628 crossrefType "proceedings-article" @default.
- W2560114628 hasAuthorship W2560114628A5025746046 @default.
- W2560114628 hasAuthorship W2560114628A5039376421 @default.
- W2560114628 hasAuthorship W2560114628A5039635841 @default.
- W2560114628 hasAuthorship W2560114628A5040230220 @default.
- W2560114628 hasAuthorship W2560114628A5053832875 @default.
- W2560114628 hasAuthorship W2560114628A5062987438 @default.
- W2560114628 hasAuthorship W2560114628A5074197659 @default.
- W2560114628 hasConcept C104317684 @default.
- W2560114628 hasConcept C127716648 @default.
- W2560114628 hasConcept C159654299 @default.
- W2560114628 hasConcept C179185449 @default.
- W2560114628 hasConcept C182704531 @default.
- W2560114628 hasConcept C194583182 @default.
- W2560114628 hasConcept C202751555 @default.
- W2560114628 hasConcept C203014093 @default.
- W2560114628 hasConcept C2780989783 @default.
- W2560114628 hasConcept C36823959 @default.
- W2560114628 hasConcept C502942594 @default.
- W2560114628 hasConcept C54355233 @default.
- W2560114628 hasConcept C6929976 @default.
- W2560114628 hasConcept C71924100 @default.
- W2560114628 hasConcept C86803240 @default.
- W2560114628 hasConcept C95444343 @default.
- W2560114628 hasConceptScore W2560114628C104317684 @default.
- W2560114628 hasConceptScore W2560114628C127716648 @default.
- W2560114628 hasConceptScore W2560114628C159654299 @default.
- W2560114628 hasConceptScore W2560114628C179185449 @default.
- W2560114628 hasConceptScore W2560114628C182704531 @default.
- W2560114628 hasConceptScore W2560114628C194583182 @default.
- W2560114628 hasConceptScore W2560114628C202751555 @default.
- W2560114628 hasConceptScore W2560114628C203014093 @default.
- W2560114628 hasConceptScore W2560114628C2780989783 @default.
- W2560114628 hasConceptScore W2560114628C36823959 @default.
- W2560114628 hasConceptScore W2560114628C502942594 @default.
- W2560114628 hasConceptScore W2560114628C54355233 @default.
- W2560114628 hasConceptScore W2560114628C6929976 @default.
- W2560114628 hasConceptScore W2560114628C71924100 @default.
- W2560114628 hasConceptScore W2560114628C86803240 @default.
- W2560114628 hasConceptScore W2560114628C95444343 @default.
- W2560114628 hasLocation W25601146281 @default.
- W2560114628 hasOpenAccess W2560114628 @default.
- W2560114628 hasPrimaryLocation W25601146281 @default.
- W2560114628 hasRelatedWork W1443226157 @default.
- W2560114628 hasRelatedWork W1601107665 @default.
- W2560114628 hasRelatedWork W1999306221 @default.
- W2560114628 hasRelatedWork W2026387078 @default.
- W2560114628 hasRelatedWork W2028085984 @default.
- W2560114628 hasRelatedWork W2112331258 @default.
- W2560114628 hasRelatedWork W2182574466 @default.
- W2560114628 hasRelatedWork W2297938062 @default.
- W2560114628 hasRelatedWork W2324809753 @default.
- W2560114628 hasRelatedWork W2474744806 @default.
- W2560114628 hasRelatedWork W2547047591 @default.
- W2560114628 hasRelatedWork W2568125248 @default.
- W2560114628 hasRelatedWork W2586832877 @default.
- W2560114628 hasRelatedWork W2587589218 @default.
- W2560114628 hasRelatedWork W2593216925 @default.
- W2560114628 hasRelatedWork W2980926250 @default.
- W2560114628 hasRelatedWork W3033020384 @default.
- W2560114628 hasRelatedWork W3096801752 @default.
- W2560114628 hasRelatedWork W3211109518 @default.
- W2560114628 hasRelatedWork W91744844 @default.
- W2560114628 isParatext "false" @default.
- W2560114628 isRetracted "false" @default.
- W2560114628 magId "2560114628" @default.
- W2560114628 workType "article" @default.