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- W2560147472 abstract "To develop a novel β1-adrenoceptor selective radiotracer, 99mTc-labeld N-(2-aminoethyl)-3-(4-(2-hydroxy-3-(isopropylaminopropoxy)phenyl)propanamide ([ 99mTc]1) was prepared by incorporating [ 99mTcO4 ]− into the precursor 3. Radiotracer [ 99mTc]1 was optimized in several reaction conditions for kit-type preparation of 99mTc-radiopharmaceuticals. The radiochemical yield was around 95% (non-decay corrected) within 30 s labeling time and radiochemical purity showed over 98%. In image studies, [ 99mTc]1 provided a good heart accumulation, whereas liver and lung uptakes showed relatively low at initial time. Furthermore, [ 99mTc]1 images at 25 min post-injection provided a clearly visible cardiac image with high contrast. To confirm the β1-adrenoceptor-binding specificity of [ 99mTc]1, a blocking experiment was performed. In vivo blocking with excess esmolol (18 mg/kg) or atenolol (2 mg/kg) resulted in significantly reduced radioactivity uptake in the heart around 92 and 76%, respectively. The results suggested that [ 99mTc]1 might be of worth applying to the assessment of β1-adrenoceptor expression in the heart diseases." @default.
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- W2560147472 date "2016-12-01" @default.
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- W2560147472 title "Synthesis andIn VivoEvaluation of a Kit-Type99mTc-labeledN-(2-Aminoethyl)-3-(4-(2-hydroxy-3-(isopropylaminopropoxy)phenyl)propanamide as a Selective β1-Adrenoceptor-binding SPECT Radiotracer" @default.
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- W2560147472 doi "https://doi.org/10.1002/bkcs.11027" @default.
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