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- W2560160659 abstract "The preparation of 2,6-substituted piperidine derivatives through diastereoselective C–H functionalization of corresponding nitrogen heterocycles represents an appealing protocol and yet remains a formidable challenge. Here, we describe a stereochemically complementary oxidative C–H functionalization of N-carbamoyl tetrahydropyridines with a wide variety of building blocks, providing either the cis- or trans-2,6-substituted piperidines with diverse patterns of functionalities. The mild metal-free process exhibits excellent regio- and diastereoselectivities as well as functional group tolerance. The synthetic utilities in natural product and analogue syntheses are also described." @default.
- W2560160659 created "2016-12-16" @default.
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- W2560160659 date "2016-12-08" @default.
- W2560160659 modified "2023-10-12" @default.
- W2560160659 title "Diastereoselectively Complementary C–H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines" @default.
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- W2560160659 doi "https://doi.org/10.1021/acs.orglett.6b03372" @default.
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