Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560248925> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2560248925 abstract "Using Duplex Sequencing, the most accurate sequencing technology currently available, we recently reported the novel finding that mutations in TP53, the most commonly mutated gene in cancer, are present at a very low frequency in non-cancerous tissues of women with and without ovarian cancer (1). These mutations were mostly non-synonymous, clustered in common TP53 cancer-associated hotspot codons and frequently led to an inactive protein. Thus, the mutations were not simply random, but appeared to have arisen through positive selection, akin to that occurring in tumors, yet in normal tissue. In most patients, multiple “biological background” mutations were simultaneously present, and mutation abundance increased with patient age. Taken together, our observations support the striking conclusion that clonal evolutionary processes typically thought of as operative only in neoplasia are, in fact, a ubiquitous part of normal aging." @default.
- W2560248925 created "2016-12-16" @default.
- W2560248925 creator A5028113408 @default.
- W2560248925 creator A5054082017 @default.
- W2560248925 creator A5059543541 @default.
- W2560248925 date "2016-11-24" @default.
- W2560248925 modified "2023-09-26" @default.
- W2560248925 title "Cancer-like mutations in non-cancer tissue: towards a better understanding of multistep carcinogenesis" @default.
- W2560248925 doi "https://doi.org/10.21037/10644" @default.
- W2560248925 hasPublicationYear "2016" @default.
- W2560248925 type Work @default.
- W2560248925 sameAs 2560248925 @default.
- W2560248925 citedByCount "0" @default.
- W2560248925 crossrefType "journal-article" @default.
- W2560248925 hasAuthorship W2560248925A5028113408 @default.
- W2560248925 hasAuthorship W2560248925A5054082017 @default.
- W2560248925 hasAuthorship W2560248925A5059543541 @default.
- W2560248925 hasConcept C104317684 @default.
- W2560248925 hasConcept C121608353 @default.
- W2560248925 hasConcept C2780427987 @default.
- W2560248925 hasConcept C501734568 @default.
- W2560248925 hasConcept C502942594 @default.
- W2560248925 hasConcept C54355233 @default.
- W2560248925 hasConcept C555283112 @default.
- W2560248925 hasConcept C86803240 @default.
- W2560248925 hasConceptScore W2560248925C104317684 @default.
- W2560248925 hasConceptScore W2560248925C121608353 @default.
- W2560248925 hasConceptScore W2560248925C2780427987 @default.
- W2560248925 hasConceptScore W2560248925C501734568 @default.
- W2560248925 hasConceptScore W2560248925C502942594 @default.
- W2560248925 hasConceptScore W2560248925C54355233 @default.
- W2560248925 hasConceptScore W2560248925C555283112 @default.
- W2560248925 hasConceptScore W2560248925C86803240 @default.
- W2560248925 hasIssue "6" @default.
- W2560248925 hasLocation W25602489251 @default.
- W2560248925 hasOpenAccess W2560248925 @default.
- W2560248925 hasPrimaryLocation W25602489251 @default.
- W2560248925 hasRelatedWork W1186115315 @default.
- W2560248925 hasRelatedWork W1597704210 @default.
- W2560248925 hasRelatedWork W1970193795 @default.
- W2560248925 hasRelatedWork W1997822512 @default.
- W2560248925 hasRelatedWork W2000905326 @default.
- W2560248925 hasRelatedWork W2029939216 @default.
- W2560248925 hasRelatedWork W2086500513 @default.
- W2560248925 hasRelatedWork W2110545114 @default.
- W2560248925 hasRelatedWork W2313176063 @default.
- W2560248925 hasRelatedWork W2335647268 @default.
- W2560248925 hasRelatedWork W2394818201 @default.
- W2560248925 hasRelatedWork W2418103777 @default.
- W2560248925 hasRelatedWork W2521657296 @default.
- W2560248925 hasRelatedWork W2600010479 @default.
- W2560248925 hasRelatedWork W2752575514 @default.
- W2560248925 hasRelatedWork W2795707203 @default.
- W2560248925 hasRelatedWork W2935272569 @default.
- W2560248925 hasRelatedWork W2943826485 @default.
- W2560248925 hasRelatedWork W3086142151 @default.
- W2560248925 hasRelatedWork W3208146656 @default.
- W2560248925 hasVolume "5" @default.
- W2560248925 isParatext "false" @default.
- W2560248925 isRetracted "false" @default.
- W2560248925 magId "2560248925" @default.
- W2560248925 workType "article" @default.