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• W2560253919 endingPage "2046" @default.
• W2560253919 startingPage "2046" @default.
• W2560253919 abstract "In the present work, four green processes have been compared to evaluate their potential to obtain rosemary extracts with in vitro anti-proliferative activity against two colon cancer cell lines (HT-29 and HCT116). The processes, carried out under optimal conditions, were: (1) pressurized liquid extraction (PLE, using an hydroalcoholic mixture as solvent) at lab-scale; (2) Single-step supercritical fluid extraction (SFE) at pilot scale; (3) Intensified two-step sequential SFE at pilot scale; (4) Integrated PLE plus supercritical antisolvent fractionation (SAF) at pilot scale. Although higher extraction yields were achieved by using PLE (38.46% dry weight), this extract provided the lowest anti-proliferative activity with no observed cytotoxic effects at the assayed concentrations. On the other hand, extracts obtained using the PLE + SAF process provided the most active rosemary extracts against both colon cancer cell lines, with LC50 ranging from 11.2 to 12.4 µg/mL and from 21.8 to 31.9 µg/mL for HCT116 and HT-29, respectively. In general, active rosemary extracts were characterized by containing carnosic acid (CA) and carnosol (CS) at concentrations above 263.7 and 33.9 mg/g extract, respectively. Some distinct compounds have been identified in the SAF extracts (rosmaridiphenol and safficinolide), suggesting their possible role as additional contributors to the observed strong anti-proliferative activity of CA and CS in SAF extracts." @default.
• W2560253919 created "2016-12-16" @default.
• W2560253919 creator A5003484414 @default.
• W2560253919 creator A5014150674 @default.
• W2560253919 creator A5057342981 @default.
• W2560253919 creator A5067650831 @default.
• W2560253919 date "2016-12-07" @default.
• W2560253919 modified "2023-10-18" @default.
• W2560253919 title "Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells" @default.
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• W2560253919 doi "https://doi.org/10.3390/ijms17122046" @default.
• W2560253919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5187846" @default.
• W2560253919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27941607" @default.
• W2560253919 hasPublicationYear "2016" @default.
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