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• W2560255046 abstract "Significance Glioblastoma, the most common primary malignant brain tumor in adults, remains challenging despite multimodality therapy, necessitating the discovery of new therapies. Nicotinamide adenine dinucleotide (NAD + ) plays a pivotal role in cancer cell metabolism, but how NAD + impacts functional signaling events in glioblastoma is not well understood. We provide clinical evidence that high expression of NAMPT, the rate-limiting step in NAD + biosynthesis, in glioblastoma tumors is associated with poor overall survival in patients, and demonstrate NAMPT and NAD + are required for the maintenance of patient-derived glioblastoma stem-like cells (GSCs). Moreover, we delineate a NAD + -dependent transcriptional program that governs GSC self-renewal and dictates the radiation resistance of these cells. These findings identify potential new therapeutic avenues for the treatment of glioblastoma." @default.
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• W2560255046 date "2016-12-07" @default.
• W2560255046 modified "2023-10-15" @default.
• W2560255046 title "An NAD ⁺ -dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma" @default.
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• W2560255046 doi "https://doi.org/10.1073/pnas.1610921114" @default.
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