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- W2560290131 endingPage "365" @default.
- W2560290131 startingPage "353" @default.
- W2560290131 abstract "Genome engineering using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated nuclease 9 (Cas9) technology is revolutionizing biomedical research. CRISPR-Cas9 enables precise editing of genes in a wide variety of cells and organisms, thereby accelerating molecular studies via targeted mutagenesis, epitope tagging, and other custom genetic modifications. Here, we illustrate the CRISPR-Cas9 methodology by focusing on Capicua (Cic), a nuclear transcriptional repressor directly phosphorylated and inactivated by ERK/MAPK. Specifically, we use CRISPR-Cas9 for targeting an ERK docking site of Drosophila Cic, thus generating ERK-insensitive mutants of this important signaling sensor." @default.
- W2560290131 created "2016-12-16" @default.
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- W2560290131 date "2016-12-07" @default.
- W2560290131 modified "2023-10-14" @default.
- W2560290131 title "Using CRISPR-Cas9 to Study ERK Signaling in Drosophila" @default.
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- W2560290131 doi "https://doi.org/10.1007/978-1-4939-6424-6_26" @default.
- W2560290131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27924580" @default.
- W2560290131 hasPublicationYear "2016" @default.
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