Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560362375> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2560362375 abstract "A 12-year-old neutered male pug suffered cardiac arrest and died under general anaesthesia during diagnostic imaging for evaluation of exercise intolerance and respiratory crisis. Histopathological evaluation revealed two types of storage material, glycolipid and lipopigment, having differential distributions in multiple organs. The heart was most strikingly affected and other less affected tissues included the liver, brain, kidneys and skin. Cardiomyocytes were swollen with extensive sarcoplasmic vacuolation together with coalescing areas of myocardial fibrosis. Transmission electron microscopy revealed irregular myelin-like structures and complex concentric lamellar bodies dominating the sarcoplasm and displacing myofibrils. These findings were consistent with a lysosomal storage disease (LSD) as the cause of cardiac disease and death. The unique clinical presentation, histomorphology and ultrastructural features of the material suggested a glycolipid storage disease most closely resembling Anderson-Fabry (Fabry) disease in man. Fabry disease is a LSD that can present in later life and is characterized by loss of α-galactosidase A function and, often, accumulation of glycosphingolipids in tissues including the heart, kidneys, vascular endothelium and smooth muscle." @default.
- W2560362375 created "2016-12-16" @default.
- W2560362375 creator A5037694592 @default.
- W2560362375 creator A5047474850 @default.
- W2560362375 creator A5057239678 @default.
- W2560362375 creator A5071939353 @default.
- W2560362375 date "2017-02-01" @default.
- W2560362375 modified "2023-09-27" @default.
- W2560362375 title "Clinicopathological Features of Cardiac Glycolipid Storage Disease in an Adult Pug" @default.
- W2560362375 cites W1554492768 @default.
- W2560362375 cites W168009955 @default.
- W2560362375 cites W186549850 @default.
- W2560362375 cites W1975422411 @default.
- W2560362375 cites W1995151721 @default.
- W2560362375 cites W2064150677 @default.
- W2560362375 cites W2092976540 @default.
- W2560362375 cites W2101425200 @default.
- W2560362375 cites W2136284882 @default.
- W2560362375 cites W2146371581 @default.
- W2560362375 cites W2148992517 @default.
- W2560362375 cites W2150288618 @default.
- W2560362375 cites W2157258787 @default.
- W2560362375 cites W2192455980 @default.
- W2560362375 cites W233031319 @default.
- W2560362375 cites W81133764 @default.
- W2560362375 doi "https://doi.org/10.1016/j.jcpa.2016.10.013" @default.
- W2560362375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27974158" @default.
- W2560362375 hasPublicationYear "2017" @default.
- W2560362375 type Work @default.
- W2560362375 sameAs 2560362375 @default.
- W2560362375 citedByCount "0" @default.
- W2560362375 crossrefType "journal-article" @default.
- W2560362375 hasAuthorship W2560362375A5037694592 @default.
- W2560362375 hasAuthorship W2560362375A5047474850 @default.
- W2560362375 hasAuthorship W2560362375A5057239678 @default.
- W2560362375 hasAuthorship W2560362375A5071939353 @default.
- W2560362375 hasConcept C105702510 @default.
- W2560362375 hasConcept C126322002 @default.
- W2560362375 hasConcept C139966638 @default.
- W2560362375 hasConcept C142724271 @default.
- W2560362375 hasConcept C158617107 @default.
- W2560362375 hasConcept C203014093 @default.
- W2560362375 hasConcept C22222904 @default.
- W2560362375 hasConcept C2777404818 @default.
- W2560362375 hasConcept C2777687718 @default.
- W2560362375 hasConcept C2778198053 @default.
- W2560362375 hasConcept C2778797674 @default.
- W2560362375 hasConcept C2779134260 @default.
- W2560362375 hasConcept C2780875844 @default.
- W2560362375 hasConcept C2909637497 @default.
- W2560362375 hasConcept C71924100 @default.
- W2560362375 hasConcept C86803240 @default.
- W2560362375 hasConcept C87555872 @default.
- W2560362375 hasConcept C95444343 @default.
- W2560362375 hasConceptScore W2560362375C105702510 @default.
- W2560362375 hasConceptScore W2560362375C126322002 @default.
- W2560362375 hasConceptScore W2560362375C139966638 @default.
- W2560362375 hasConceptScore W2560362375C142724271 @default.
- W2560362375 hasConceptScore W2560362375C158617107 @default.
- W2560362375 hasConceptScore W2560362375C203014093 @default.
- W2560362375 hasConceptScore W2560362375C22222904 @default.
- W2560362375 hasConceptScore W2560362375C2777404818 @default.
- W2560362375 hasConceptScore W2560362375C2777687718 @default.
- W2560362375 hasConceptScore W2560362375C2778198053 @default.
- W2560362375 hasConceptScore W2560362375C2778797674 @default.
- W2560362375 hasConceptScore W2560362375C2779134260 @default.
- W2560362375 hasConceptScore W2560362375C2780875844 @default.
- W2560362375 hasConceptScore W2560362375C2909637497 @default.
- W2560362375 hasConceptScore W2560362375C71924100 @default.
- W2560362375 hasConceptScore W2560362375C86803240 @default.
- W2560362375 hasConceptScore W2560362375C87555872 @default.
- W2560362375 hasConceptScore W2560362375C95444343 @default.
- W2560362375 hasLocation W25603623751 @default.
- W2560362375 hasLocation W25603623752 @default.
- W2560362375 hasOpenAccess W2560362375 @default.
- W2560362375 hasPrimaryLocation W25603623751 @default.
- W2560362375 hasRelatedWork W192665483 @default.
- W2560362375 hasRelatedWork W1983068226 @default.
- W2560362375 hasRelatedWork W1985768899 @default.
- W2560362375 hasRelatedWork W2089592493 @default.
- W2560362375 hasRelatedWork W2097776291 @default.
- W2560362375 hasRelatedWork W2155684540 @default.
- W2560362375 hasRelatedWork W2328023011 @default.
- W2560362375 hasRelatedWork W2412798610 @default.
- W2560362375 hasRelatedWork W2805237671 @default.
- W2560362375 hasRelatedWork W2782095422 @default.
- W2560362375 isParatext "false" @default.
- W2560362375 isRetracted "false" @default.
- W2560362375 magId "2560362375" @default.
- W2560362375 workType "article" @default.