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- W2560403605 abstract "Cell penetrating peptides (CPPs) have been used for a myriad of cellular delivery applications and were recently explored for delivery of antisense agents such as peptide nucleic acids (PNAs) for bacterial inhibition. In this report, we show that microfluidic electroporation delivery dramatically increases the bioavailability of CPP-PNAs to kill Salmonella macrophages which is typical in animals and humans. Electroporation delivers the molecules without involving endocytosis and greatly increases the antisense effect. The decrease in the average number of Salmonella per macrophage under a 1200 V/cm and 5 ms pulse was a factor of 9 higher than that without electroporation." @default.
- W2560403605 created "2016-12-16" @default.
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- W2560403605 date "2014-01-01" @default.
- W2560403605 modified "2023-09-27" @default.
- W2560403605 title "MICROFLUIDIC ELECTROPORATION FOR DELIVERY OF CELL- PENETRATING PEPTIDE CONJUGATES OF PEPTIDE NUCLEIC ACIDS (PNA) FOR ANTISENSE INHIBITION OF INTRACELLULAR BACTERIA" @default.
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