FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560416092> ?p ?o ?g. }

• W2560416092 endingPage "70" @default.
• W2560416092 startingPage "57" @default.
• W2560416092 abstract "Ischemia-induced stroke is the most common disease of the nervous system and is associated with a high mortality rate worldwide. Cerebral ischemia may lead to remote organ dysfunction, particular in the lungs, resulting in lung injury. Nowadays, bone marrow-derived mesenchymal stem cells (BMSCs) are widely studied in clinical trials as they may provide an effective solution to the treatment of neurological and cardiac diseases; however, the underlying molecular mechanisms remain unknown. In this study, a model of permanent focal cerebral ischemia-induced lung injury was successfully established and confirmed by neurological evaluation and lung injury scores. We demonstrated that the transplantation of BMSCs (passage 3) via the tail vein into the lung tissues attenuated lung injury. In order to elucidate the underlying molecular mechanisms, we analyzed the gene expression profiles in lung tissues from the rats with focal cerebral ischemia and transplanted with BMSCs using a Gene microarray. Moreover, the Gene Ontology database was employed to determine gene function. We found that the phosphoinositide 3-kinase (PI3K)-AKT signaling pathway, transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF) were downregulated in the BMSC transplantation groups, compared with the control group. These results suggested that BMSC transplantation may attenuate lung injury following focal cerebral ischemia and that this effect is associated with the downregulation of TGF-β, PDGF and the PI3K-AKT pathway." @default.
• W2560416092 created "2016-12-16" @default.
• W2560416092 creator A5034473067 @default.
• W2560416092 creator A5048047500 @default.
• W2560416092 creator A5072312000 @default.
• W2560416092 creator A5087548970 @default.
• W2560416092 date "2016-12-06" @default.
• W2560416092 modified "2023-10-14" @default.
• W2560416092 title "Microarray expression profiles of genes in lung tissues of rats subjected to focal cerebral ischemia-induced lung injury following bone marrow-derived mesenchymal stem cell transplantation" @default.
• W2560416092 cites W1537844617 @default.
• W2560416092 cites W1589349659 @default.
• W2560416092 cites W1600560134 @default.
• W2560416092 cites W1869723732 @default.
• W2560416092 cites W1932064144 @default.
• W2560416092 cites W1964332383 @default.
• W2560416092 cites W1969861155 @default.
• W2560416092 cites W1971722602 @default.
• W2560416092 cites W1978256141 @default.
• W2560416092 cites W1979043688 @default.
• W2560416092 cites W1985516751 @default.
• W2560416092 cites W1989398852 @default.
• W2560416092 cites W1989855642 @default.
• W2560416092 cites W1991546524 @default.
• W2560416092 cites W1995252337 @default.
• W2560416092 cites W2009524610 @default.
• W2560416092 cites W2011610612 @default.
• W2560416092 cites W2015164426 @default.
• W2560416092 cites W2015872392 @default.
• W2560416092 cites W2021659502 @default.
• W2560416092 cites W2024091903 @default.
• W2560416092 cites W2025120210 @default.
• W2560416092 cites W2033391749 @default.
• W2560416092 cites W2035198565 @default.
• W2560416092 cites W2044823316 @default.
• W2560416092 cites W2061771923 @default.
• W2560416092 cites W2070160843 @default.
• W2560416092 cites W2076695016 @default.
• W2560416092 cites W2084276316 @default.
• W2560416092 cites W2087804062 @default.
• W2560416092 cites W2091802988 @default.
• W2560416092 cites W2094326857 @default.
• W2560416092 cites W2095852864 @default.
• W2560416092 cites W2096024431 @default.
• W2560416092 cites W2106411632 @default.
• W2560416092 cites W2106559955 @default.
• W2560416092 cites W2108790161 @default.
• W2560416092 cites W2112302625 @default.
• W2560416092 cites W2117264420 @default.
• W2560416092 cites W2118976802 @default.
• W2560416092 cites W2120549828 @default.
• W2560416092 cites W2129303004 @default.
• W2560416092 cites W2132943208 @default.
• W2560416092 cites W2140364077 @default.
• W2560416092 cites W2141041714 @default.
• W2560416092 cites W2147156629 @default.
• W2560416092 cites W2150103989 @default.
• W2560416092 cites W2155835218 @default.
• W2560416092 cites W2156298842 @default.
• W2560416092 cites W2161733194 @default.
• W2560416092 cites W2182355171 @default.
• W2560416092 cites W2182448933 @default.
• W2560416092 cites W2288463281 @default.
• W2560416092 cites W2312343074 @default.
• W2560416092 cites W2322137256 @default.
• W2560416092 cites W2343186472 @default.
• W2560416092 cites W2351718666 @default.
• W2560416092 cites W2391638254 @default.
• W2560416092 cites W2408001221 @default.
• W2560416092 cites W2435817531 @default.
• W2560416092 cites W2436507926 @default.
• W2560416092 cites W2620241325 @default.
• W2560416092 cites W4240511213 @default.
• W2560416092 cites W4253918859 @default.
• W2560416092 cites W4293084779 @default.
• W2560416092 doi "https://doi.org/10.3892/ijmm.2016.2819" @default.
• W2560416092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5179184" @default.
• W2560416092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27922691" @default.
• W2560416092 hasPublicationYear "2016" @default.
• W2560416092 type Work @default.
• W2560416092 sameAs 2560416092 @default.
• W2560416092 citedByCount "5" @default.
• W2560416092 countsByYear W25604160922018 @default.
• W2560416092 countsByYear W25604160922019 @default.
• W2560416092 countsByYear W25604160922020 @default.
• W2560416092 countsByYear W25604160922022 @default.
• W2560416092 countsByYear W25604160922023 @default.
• W2560416092 crossrefType "journal-article" @default.
• W2560416092 hasAuthorship W2560416092A5034473067 @default.
• W2560416092 hasAuthorship W2560416092A5048047500 @default.
• W2560416092 hasAuthorship W2560416092A5072312000 @default.
• W2560416092 hasAuthorship W2560416092A5087548970 @default.
• W2560416092 hasBestOaLocation W25604160921 @default.
• W2560416092 hasConcept C126322002 @default.
• W2560416092 hasConcept C142724271 @default.
• W2560416092 hasConcept C2777714996 @default.
• W2560416092 hasConcept C2911091166 @default.
• W2560416092 hasConcept C502942594 @default.
• W2560416092 hasConcept C541997718 @default.

• next