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- W2560421036 abstract "An easily obtainable thiol-selective labeling reagent [18F]FBSEM (N-[2-(4-[18F]fluoro-N-methylbenzenesulfonamido)ethyl]maleimide) was developed. The advantage of the design is that the precursor and [18F]FBSEM have the same backbone and backbone construction is not required; in contrast, known thiol-specific labeling reagents do require backbone construction, and this is thought to be the cause of their complicated synthesis. [18F]FBSEM was successfully obtained in higher yield (25%) and in a simpler way (two fluorination and deprotection steps in 65 min) than the widely used [18F]FBEM (N-[2-(4-[18F]fluorobenzamide)ethyl]maleimide). The labeling efficacy of [18F]FBSEM was confirmed by conjugation with glutathione. [18F]FBSEM is a promising labeling agent for proteins." @default.
- W2560421036 created "2016-12-16" @default.
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- W2560421036 date "2017-01-13" @default.
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- W2560421036 title "Design and Synthesis of an Easily Obtainable Maleimide Reagent <i>N</i>-[2-(4-[<sup>18</sup>F]fluoro-<i>N</i>-methylbenzenesulfonamido)ethyl]maleimide ([<sup>18</sup>F]FBSEM) to Radiolabel Thiols in Proteins" @default.
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- W2560421036 doi "https://doi.org/10.1021/acs.bioconjchem.6b00707" @default.
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