FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560423029> ?p ?o ?g. }

• W2560423029 endingPage "338" @default.
• W2560423029 startingPage "332" @default.
• W2560423029 abstract "The renal outer medullary potassium (ROMK) channel mediates potassium recycling and facilitates sodium reabsorption through the Na+/K+/2Cl- cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Evidence from the phenotype of humans and rodents with functional ROMK deficiency supports the contention that selective ROMK inhibitors (ROMKi) will represent a novel diuretic with potential of therapeutic benefit for hypertension. ROMKi have recently been synthesized by Merck & Co, Inc. The present studies were designed to examine the effects of ROMKi B on systemic hemodynamics, renal function and structure, and vascular function in Dahl salt-sensitive rats. Four experimental groups-control, high-salt diet alone; ROMKi B 3 mg·kg-1·d-1; ROMKi B 10 mg·kg-1·d-1; and hydrochlorothiazide 25 mg·kg-1·d-1-were included in prophylactic (from week 1 to week 9 on high-salt diet) and therapeutic studies (from week 5 to week 9 on high-salt diet), respectively. ROMKi B produced sustained blood pressure reduction and improved renal and vascular function and histological alterations induced by a high-salt diet. ROMKi B was superior to hydrochlorothiazide at reducing blood pressure. Furthermore, ROMKi B provided beneficial effects on both the plasma lipid profile and bone mineral density. Chronic ROMK inhibition not only prevented but also reversed the development of hypertension and end-organ damage in Dahl salt-sensitive rats. Our findings suggest a potential utility of ROMKi B as a novel antihypertensive agent, particularly for the treatment of the salt-sensitive hypertension patient population." @default.
• W2560423029 created "2016-12-16" @default.
• W2560423029 creator A5001806893 @default.
• W2560423029 creator A5004689022 @default.
• W2560423029 creator A5005164117 @default.
• W2560423029 creator A5020580070 @default.
• W2560423029 creator A5034281578 @default.
• W2560423029 creator A5037229994 @default.
• W2560423029 creator A5060467850 @default.
• W2560423029 creator A5063733458 @default.
• W2560423029 creator A5064222083 @default.
• W2560423029 creator A5070659245 @default.
• W2560423029 creator A5073411736 @default.
• W2560423029 creator A5075343261 @default.
• W2560423029 creator A5075474577 @default.
• W2560423029 creator A5079788051 @default.
• W2560423029 date "2017-02-01" @default.
• W2560423029 modified "2023-09-24" @default.
• W2560423029 title "Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats" @default.
• W2560423029 cites W1969319759 @default.
• W2560423029 cites W1995826486 @default.
• W2560423029 cites W2010100568 @default.
• W2560423029 cites W2015344956 @default.
• W2560423029 cites W2047155389 @default.
• W2560423029 cites W2068448909 @default.
• W2560423029 cites W2087626473 @default.
• W2560423029 cites W2096987834 @default.
• W2560423029 cites W2108043636 @default.
• W2560423029 cites W2123906214 @default.
• W2560423029 cites W2131027628 @default.
• W2560423029 cites W2135779265 @default.
• W2560423029 cites W2155074646 @default.
• W2560423029 cites W2156588647 @default.
• W2560423029 cites W2161660118 @default.
• W2560423029 cites W2161935988 @default.
• W2560423029 cites W2417574108 @default.
• W2560423029 cites W4211170441 @default.
• W2560423029 doi "https://doi.org/10.1161/hypertensionaha.116.08358" @default.
• W2560423029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27920129" @default.
• W2560423029 hasPublicationYear "2017" @default.
• W2560423029 type Work @default.
• W2560423029 sameAs 2560423029 @default.
• W2560423029 citedByCount "13" @default.
• W2560423029 countsByYear W25604230292017 @default.
• W2560423029 countsByYear W25604230292018 @default.
• W2560423029 countsByYear W25604230292019 @default.
• W2560423029 countsByYear W25604230292020 @default.
• W2560423029 countsByYear W25604230292021 @default.
• W2560423029 countsByYear W25604230292022 @default.
• W2560423029 crossrefType "journal-article" @default.
• W2560423029 hasAuthorship W2560423029A5001806893 @default.
• W2560423029 hasAuthorship W2560423029A5004689022 @default.
• W2560423029 hasAuthorship W2560423029A5005164117 @default.
• W2560423029 hasAuthorship W2560423029A5020580070 @default.
• W2560423029 hasAuthorship W2560423029A5034281578 @default.
• W2560423029 hasAuthorship W2560423029A5037229994 @default.
• W2560423029 hasAuthorship W2560423029A5060467850 @default.
• W2560423029 hasAuthorship W2560423029A5063733458 @default.
• W2560423029 hasAuthorship W2560423029A5064222083 @default.
• W2560423029 hasAuthorship W2560423029A5070659245 @default.
• W2560423029 hasAuthorship W2560423029A5073411736 @default.
• W2560423029 hasAuthorship W2560423029A5075343261 @default.
• W2560423029 hasAuthorship W2560423029A5075474577 @default.
• W2560423029 hasAuthorship W2560423029A5079788051 @default.
• W2560423029 hasBestOaLocation W25604230291 @default.
• W2560423029 hasConcept C126322002 @default.
• W2560423029 hasConcept C134018914 @default.
• W2560423029 hasConcept C159641895 @default.
• W2560423029 hasConcept C185592680 @default.
• W2560423029 hasConcept C2779918671 @default.
• W2560423029 hasConcept C2780091579 @default.
• W2560423029 hasConcept C2780361556 @default.
• W2560423029 hasConcept C56906281 @default.
• W2560423029 hasConcept C71924100 @default.
• W2560423029 hasConcept C84393581 @default.
• W2560423029 hasConcept C98274493 @default.
• W2560423029 hasConceptScore W2560423029C126322002 @default.
• W2560423029 hasConceptScore W2560423029C134018914 @default.
• W2560423029 hasConceptScore W2560423029C159641895 @default.
• W2560423029 hasConceptScore W2560423029C185592680 @default.
• W2560423029 hasConceptScore W2560423029C2779918671 @default.
• W2560423029 hasConceptScore W2560423029C2780091579 @default.
• W2560423029 hasConceptScore W2560423029C2780361556 @default.
• W2560423029 hasConceptScore W2560423029C56906281 @default.
• W2560423029 hasConceptScore W2560423029C71924100 @default.
• W2560423029 hasConceptScore W2560423029C84393581 @default.
• W2560423029 hasConceptScore W2560423029C98274493 @default.
• W2560423029 hasIssue "2" @default.
• W2560423029 hasLocation W25604230291 @default.
• W2560423029 hasLocation W25604230292 @default.
• W2560423029 hasOpenAccess W2560423029 @default.
• W2560423029 hasPrimaryLocation W25604230291 @default.
• W2560423029 hasRelatedWork W1924012380 @default.
• W2560423029 hasRelatedWork W1990107430 @default.
• W2560423029 hasRelatedWork W2001915541 @default.
• W2560423029 hasRelatedWork W2072980676 @default.
• W2560423029 hasRelatedWork W2082456910 @default.
• W2560423029 hasRelatedWork W2138029694 @default.

• next