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• W2560450176 abstract "We report a set of brominated luciferins for bioluminescence imaging. These regioisomeric scaffolds were accessed by using a common synthetic route. All analogues produced light with firefly luciferase, although varying levels of emission were observed. Differences in photon output were analyzed by computation and photophysical measurements. The brightest brominated luciferin was further evaluated in cell and animal models. At low doses, the analogue outperformed the native substrate in cells. The remaining luciferins, although weak emitters with firefly luciferase, were inherently capable of light production and thus potential substrates for orthogonal mutant enzymes." @default.
• W2560450176 created "2016-12-16" @default.
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• W2560450176 date "2016-12-08" @default.
• W2560450176 modified "2023-09-30" @default.
• W2560450176 title "Brominated Luciferins Are Versatile Bioluminescent Probes" @default.
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• W2560450176 doi "https://doi.org/10.1002/cbic.201600564" @default.
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