FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560508799> ?p ?o ?g. }

• W2560508799 abstract "New genomic technologies, whilst allowing comprehensive and cost-effective access to disease-causing mutations, also increase the possibility of incidental findings unrelated to the original research question. These findings may have health, reproductive or familial implications for the research participant concerned. There are diverse opinions regarding the obligations of researchers and appropriate management strategies regarding how or whether to return this information to research participants. As the empirical data on which these arguments are based is still fairly limited, we undertook a qualitative study, using a thematic analysis approach, to explore the topic further. We interviewed members of UK NHS research ethics committees to ascertain their experiences regarding genetic incidental findings, as well as their opinions regarding future challenges and management. The interviews were transcribed, coded and analysed for common themes. Three themes emerged; facilitating participant consent, supporting the validity of consent, and risks and rights. Ethics committee members were aware of the issues raised by genetic incidental findings despite limited practical experience in the projects they have assessed. There was no consensus as to how information should be presented to potential participants during recruitment for research involving genome-wide technologies, or whether blanket or checklist-based consent was most useful. Participants also discussed the difficulties in balancing the rights and obligations of research participants, their families, researchers and clinicians when considering the return of incidental findings. Some supported overruling patient consent in order to return clinically actionable incidental findings. In the absence of national guidance on these issues, the lack of consensus evident in this study could potentially lead to disparity between research ethics committees in the way genetic research studies are appraised. A wider discussion on the suitability of the current informed consent model for complex genomic research may also be required." @default.
• W2560508799 created "2016-12-16" @default.
• W2560508799 creator A5022645971 @default.
• W2560508799 creator A5023670574 @default.
• W2560508799 creator A5037788689 @default.
• W2560508799 creator A5084307139 @default.
• W2560508799 date "2015-01-01" @default.
• W2560508799 modified "2023-09-27" @default.
• W2560508799 title "Management of Incidental Findings from Genetic Tests: Perspectives of Ethics Committee Members" @default.
• W2560508799 cites W1484112502 @default.
• W2560508799 cites W1486943396 @default.
• W2560508799 cites W1505985742 @default.
• W2560508799 cites W1608171675 @default.
• W2560508799 cites W1622527855 @default.
• W2560508799 cites W1658908529 @default.
• W2560508799 cites W189803326 @default.
• W2560508799 cites W1967295226 @default.
• W2560508799 cites W1974407984 @default.
• W2560508799 cites W1978572490 @default.
• W2560508799 cites W1983973208 @default.
• W2560508799 cites W1984379299 @default.
• W2560508799 cites W1984784025 @default.
• W2560508799 cites W1989301770 @default.
• W2560508799 cites W1996081933 @default.
• W2560508799 cites W2005129098 @default.
• W2560508799 cites W2006454796 @default.
• W2560508799 cites W2007555630 @default.
• W2560508799 cites W2008110990 @default.
• W2560508799 cites W2023569973 @default.
• W2560508799 cites W2044998777 @default.
• W2560508799 cites W2053763723 @default.
• W2560508799 cites W2059910606 @default.
• W2560508799 cites W2060757950 @default.
• W2560508799 cites W2085315239 @default.
• W2560508799 cites W2092373383 @default.
• W2560508799 cites W2111464950 @default.
• W2560508799 cites W2118005121 @default.
• W2560508799 cites W2124039618 @default.
• W2560508799 cites W2129660502 @default.
• W2560508799 cites W2130062599 @default.
• W2560508799 cites W2134210839 @default.
• W2560508799 cites W2163633684 @default.
• W2560508799 cites W2169782764 @default.
• W2560508799 cites W2171148471 @default.
• W2560508799 cites W2993880085 @default.
• W2560508799 cites W3022452870 @default.
• W2560508799 doi "https://doi.org/10.4172/2155-9627.1000219" @default.
• W2560508799 hasPublicationYear "2015" @default.
• W2560508799 type Work @default.
• W2560508799 sameAs 2560508799 @default.
• W2560508799 citedByCount "0" @default.
• W2560508799 crossrefType "journal-article" @default.
• W2560508799 hasAuthorship W2560508799A5022645971 @default.
• W2560508799 hasAuthorship W2560508799A5023670574 @default.
• W2560508799 hasAuthorship W2560508799A5037788689 @default.
• W2560508799 hasAuthorship W2560508799A5084307139 @default.
• W2560508799 hasConcept C118552586 @default.
• W2560508799 hasConcept C142724271 @default.
• W2560508799 hasConcept C144024400 @default.
• W2560508799 hasConcept C153997805 @default.
• W2560508799 hasConcept C15744967 @default.
• W2560508799 hasConcept C17744445 @default.
• W2560508799 hasConcept C180747234 @default.
• W2560508799 hasConcept C188084074 @default.
• W2560508799 hasConcept C190248442 @default.
• W2560508799 hasConcept C199539241 @default.
• W2560508799 hasConcept C204787440 @default.
• W2560508799 hasConcept C2779356329 @default.
• W2560508799 hasConcept C36289849 @default.
• W2560508799 hasConcept C39549134 @default.
• W2560508799 hasConcept C509550671 @default.
• W2560508799 hasConcept C68122502 @default.
• W2560508799 hasConcept C71924100 @default.
• W2560508799 hasConcept C74196892 @default.
• W2560508799 hasConceptScore W2560508799C118552586 @default.
• W2560508799 hasConceptScore W2560508799C142724271 @default.
• W2560508799 hasConceptScore W2560508799C144024400 @default.
• W2560508799 hasConceptScore W2560508799C153997805 @default.
• W2560508799 hasConceptScore W2560508799C15744967 @default.
• W2560508799 hasConceptScore W2560508799C17744445 @default.
• W2560508799 hasConceptScore W2560508799C180747234 @default.
• W2560508799 hasConceptScore W2560508799C188084074 @default.
• W2560508799 hasConceptScore W2560508799C190248442 @default.
• W2560508799 hasConceptScore W2560508799C199539241 @default.
• W2560508799 hasConceptScore W2560508799C204787440 @default.
• W2560508799 hasConceptScore W2560508799C2779356329 @default.
• W2560508799 hasConceptScore W2560508799C36289849 @default.
• W2560508799 hasConceptScore W2560508799C39549134 @default.
• W2560508799 hasConceptScore W2560508799C509550671 @default.
• W2560508799 hasConceptScore W2560508799C68122502 @default.
• W2560508799 hasConceptScore W2560508799C71924100 @default.
• W2560508799 hasConceptScore W2560508799C74196892 @default.
• W2560508799 hasLocation W25605087991 @default.
• W2560508799 hasOpenAccess W2560508799 @default.
• W2560508799 hasPrimaryLocation W25605087991 @default.
• W2560508799 hasRelatedWork W1511875347 @default.
• W2560508799 hasRelatedWork W1525969076 @default.
• W2560508799 hasRelatedWork W1888689427 @default.
• W2560508799 hasRelatedWork W1987141057 @default.
• W2560508799 hasRelatedWork W1990147405 @default.

• next