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• W2560573671 abstract "Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with S1647T variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus reprogramming system. The transgene-free iPSC showed pluripotency confirmed by immunofluorescent staining for pluripotency markers and differentiated into the 3 germ layers in vivo. The iPSC line also showed normal karyotype. This cellular model will be useful for further function studies and therapeutic screening." @default.
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• W2560573671 date "2017-01-01" @default.
• W2560573671 modified "2023-10-14" @default.
• W2560573671 title "Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson’s disease linked LRRK2 variant S1647T" @default.
• W2560573671 cites W1967025085 @default.
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• W2560573671 doi "https://doi.org/10.1016/j.scr.2016.12.010" @default.
• W2560573671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28395805" @default.
• W2560573671 hasPublicationYear "2017" @default.
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