Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560632132> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2560632132 endingPage "246" @default.
- W2560632132 startingPage "241" @default.
- W2560632132 abstract "The clinical response of rituximab (RTX) is related to the degree of B cell depletion, although other circulating lymphocytes may be affected. We investigated the changes in lymphocyte sub-populations in rheumatoid arthritis (RA) patients treated with RTX and their relationship with the therapeutic response, with attention to natural killer (NK) cells.In fifty-one RA patients peripheral blood B and T lymphocytes and NK cells subtypes were counted by flow cytometry before and 3, 6 and 12 months after RTX administration. Patients were evaluated for disease activity with DAS28-CRP and EULAR response criteria at each visit.RTX significantly increased from baseline values CD56+3- cells (28 %, 19 % and 25 %; p<0.001, p=0.009 and p=0.004 respectively for month 3, 6 and 12) and CD56dimCD16+ cells (41%, 24% and 36%; p<0.001, p=0.001 and p<0.001 respectively for month 3, 6 and 12). CD56bri16- cells were unaffected by RTX treatment. The increase in both CD56+3- and CD56dimCD16+ cells was significantly greater in patients who were re-treated with another course of RTX at month 6 (p=0.046 and p=0.010 respectively). An inverse correlation between disease activity score and increase in NK cells was demonstrated. No significant changes were observed in CD3+, CD4+ and CD8+ cells during the whole observation period.In RA patients, RTX treatment is associated with significant and persistent increase in CD56+3- and CD56dimCD16+ NK cells. A correlation with disease activity is probable, although the association with clinical response remains to be proved." @default.
- W2560632132 created "2016-12-16" @default.
- W2560632132 creator A5006667947 @default.
- W2560632132 creator A5013752581 @default.
- W2560632132 creator A5022805733 @default.
- W2560632132 creator A5026470430 @default.
- W2560632132 creator A5038627121 @default.
- W2560632132 creator A5041057910 @default.
- W2560632132 creator A5045315263 @default.
- W2560632132 creator A5062914165 @default.
- W2560632132 date "2016-12-03" @default.
- W2560632132 modified "2023-09-23" @default.
- W2560632132 title "Rituximab increases peripheral natural killer cells in patients with rheumatoid arthritis." @default.
- W2560632132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27908302" @default.
- W2560632132 hasPublicationYear "2016" @default.
- W2560632132 type Work @default.
- W2560632132 sameAs 2560632132 @default.
- W2560632132 citedByCount "1" @default.
- W2560632132 countsByYear W25606321322022 @default.
- W2560632132 crossrefType "journal-article" @default.
- W2560632132 hasAuthorship W2560632132A5006667947 @default.
- W2560632132 hasAuthorship W2560632132A5013752581 @default.
- W2560632132 hasAuthorship W2560632132A5022805733 @default.
- W2560632132 hasAuthorship W2560632132A5026470430 @default.
- W2560632132 hasAuthorship W2560632132A5038627121 @default.
- W2560632132 hasAuthorship W2560632132A5041057910 @default.
- W2560632132 hasAuthorship W2560632132A5045315263 @default.
- W2560632132 hasAuthorship W2560632132A5062914165 @default.
- W2560632132 hasConcept C126322002 @default.
- W2560632132 hasConcept C154317977 @default.
- W2560632132 hasConcept C159654299 @default.
- W2560632132 hasConcept C167672396 @default.
- W2560632132 hasConcept C185592680 @default.
- W2560632132 hasConcept C202751555 @default.
- W2560632132 hasConcept C203014093 @default.
- W2560632132 hasConcept C2777077863 @default.
- W2560632132 hasConcept C2777575956 @default.
- W2560632132 hasConcept C2777761686 @default.
- W2560632132 hasConcept C2778102761 @default.
- W2560632132 hasConcept C2780653079 @default.
- W2560632132 hasConcept C553184892 @default.
- W2560632132 hasConcept C55493867 @default.
- W2560632132 hasConcept C71924100 @default.
- W2560632132 hasConcept C8891405 @default.
- W2560632132 hasConcept C90924648 @default.
- W2560632132 hasConceptScore W2560632132C126322002 @default.
- W2560632132 hasConceptScore W2560632132C154317977 @default.
- W2560632132 hasConceptScore W2560632132C159654299 @default.
- W2560632132 hasConceptScore W2560632132C167672396 @default.
- W2560632132 hasConceptScore W2560632132C185592680 @default.
- W2560632132 hasConceptScore W2560632132C202751555 @default.
- W2560632132 hasConceptScore W2560632132C203014093 @default.
- W2560632132 hasConceptScore W2560632132C2777077863 @default.
- W2560632132 hasConceptScore W2560632132C2777575956 @default.
- W2560632132 hasConceptScore W2560632132C2777761686 @default.
- W2560632132 hasConceptScore W2560632132C2778102761 @default.
- W2560632132 hasConceptScore W2560632132C2780653079 @default.
- W2560632132 hasConceptScore W2560632132C553184892 @default.
- W2560632132 hasConceptScore W2560632132C55493867 @default.
- W2560632132 hasConceptScore W2560632132C71924100 @default.
- W2560632132 hasConceptScore W2560632132C8891405 @default.
- W2560632132 hasConceptScore W2560632132C90924648 @default.
- W2560632132 hasIssue "2" @default.
- W2560632132 hasLocation W25606321321 @default.
- W2560632132 hasOpenAccess W2560632132 @default.
- W2560632132 hasPrimaryLocation W25606321321 @default.
- W2560632132 hasRelatedWork W119517883 @default.
- W2560632132 hasRelatedWork W1501243327 @default.
- W2560632132 hasRelatedWork W1963511249 @default.
- W2560632132 hasRelatedWork W2139645456 @default.
- W2560632132 hasRelatedWork W2169629346 @default.
- W2560632132 hasRelatedWork W2394033620 @default.
- W2560632132 hasRelatedWork W2399524791 @default.
- W2560632132 hasRelatedWork W2897393037 @default.
- W2560632132 hasRelatedWork W2903122430 @default.
- W2560632132 hasRelatedWork W2963414950 @default.
- W2560632132 hasVolume "35" @default.
- W2560632132 isParatext "false" @default.
- W2560632132 isRetracted "false" @default.
- W2560632132 magId "2560632132" @default.
- W2560632132 workType "article" @default.