Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560681683> ?p ?o ?g. }
- W2560681683 abstract "Abstract Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. We have established that clathrin-dependent endocytosis of the type-I interferon (IFN-α/β) receptor (IFNAR) is required for JAK/STAT signalling. Here we show that the internalized IFNAR1 and IFNAR2 subunits of the IFNAR complex are differentially sorted by the retromer at the early endosome. Binding of the retromer VPS35 subunit to IFNAR2 results in IFNAR2 recycling to the plasma membrane, whereas IFNAR1 is sorted to the lysosome for degradation. Depletion of VPS35 leads to abnormally prolonged residency and association of the IFNAR subunits at the early endosome, resulting in increased activation of STAT1- and IFN-dependent gene transcription. These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type-I IFN-induced JAK/STAT signalling and gene transcription." @default.
- W2560681683 created "2016-12-16" @default.
- W2560681683 creator A5005511583 @default.
- W2560681683 creator A5025791783 @default.
- W2560681683 creator A5038201165 @default.
- W2560681683 creator A5039460084 @default.
- W2560681683 creator A5055418827 @default.
- W2560681683 creator A5055459949 @default.
- W2560681683 creator A5055833721 @default.
- W2560681683 creator A5061190003 @default.
- W2560681683 creator A5062068011 @default.
- W2560681683 creator A5069951920 @default.
- W2560681683 creator A5080931242 @default.
- W2560681683 creator A5087450860 @default.
- W2560681683 creator A5090005733 @default.
- W2560681683 creator A5091734086 @default.
- W2560681683 date "2016-12-05" @default.
- W2560681683 modified "2023-10-09" @default.
- W2560681683 title "Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex" @default.
- W2560681683 cites W1494304190 @default.
- W2560681683 cites W1963890746 @default.
- W2560681683 cites W1966311581 @default.
- W2560681683 cites W1973454407 @default.
- W2560681683 cites W1975228796 @default.
- W2560681683 cites W1978149967 @default.
- W2560681683 cites W1979448464 @default.
- W2560681683 cites W1980873308 @default.
- W2560681683 cites W1984536659 @default.
- W2560681683 cites W1988983557 @default.
- W2560681683 cites W1992496728 @default.
- W2560681683 cites W1996675875 @default.
- W2560681683 cites W1999056400 @default.
- W2560681683 cites W2000177767 @default.
- W2560681683 cites W2010519082 @default.
- W2560681683 cites W2013637340 @default.
- W2560681683 cites W2030980071 @default.
- W2560681683 cites W2040580977 @default.
- W2560681683 cites W2060233546 @default.
- W2560681683 cites W2063129130 @default.
- W2560681683 cites W2063663222 @default.
- W2560681683 cites W2067080420 @default.
- W2560681683 cites W2072204570 @default.
- W2560681683 cites W2073526502 @default.
- W2560681683 cites W2074325696 @default.
- W2560681683 cites W2078844752 @default.
- W2560681683 cites W2078993960 @default.
- W2560681683 cites W2082661031 @default.
- W2560681683 cites W2085144734 @default.
- W2560681683 cites W2089330255 @default.
- W2560681683 cites W2090163065 @default.
- W2560681683 cites W2094625991 @default.
- W2560681683 cites W2097160882 @default.
- W2560681683 cites W2100454832 @default.
- W2560681683 cites W2101163066 @default.
- W2560681683 cites W2103090750 @default.
- W2560681683 cites W2107031229 @default.
- W2560681683 cites W2110337011 @default.
- W2560681683 cites W2111218879 @default.
- W2560681683 cites W2112385479 @default.
- W2560681683 cites W2116002414 @default.
- W2560681683 cites W2123830992 @default.
- W2560681683 cites W2124733101 @default.
- W2560681683 cites W2127997174 @default.
- W2560681683 cites W2132173287 @default.
- W2560681683 cites W2138897323 @default.
- W2560681683 cites W2142415307 @default.
- W2560681683 cites W2146608733 @default.
- W2560681683 cites W2168687405 @default.
- W2560681683 cites W2314207955 @default.
- W2560681683 cites W2404657003 @default.
- W2560681683 cites W585621270 @default.
- W2560681683 doi "https://doi.org/10.1038/ncomms13476" @default.
- W2560681683 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5150223" @default.
- W2560681683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27917878" @default.
- W2560681683 hasPublicationYear "2016" @default.
- W2560681683 type Work @default.
- W2560681683 sameAs 2560681683 @default.
- W2560681683 citedByCount "48" @default.
- W2560681683 countsByYear W25606816832017 @default.
- W2560681683 countsByYear W25606816832018 @default.
- W2560681683 countsByYear W25606816832019 @default.
- W2560681683 countsByYear W25606816832020 @default.
- W2560681683 countsByYear W25606816832021 @default.
- W2560681683 countsByYear W25606816832022 @default.
- W2560681683 countsByYear W25606816832023 @default.
- W2560681683 crossrefType "journal-article" @default.
- W2560681683 hasAuthorship W2560681683A5005511583 @default.
- W2560681683 hasAuthorship W2560681683A5025791783 @default.
- W2560681683 hasAuthorship W2560681683A5038201165 @default.
- W2560681683 hasAuthorship W2560681683A5039460084 @default.
- W2560681683 hasAuthorship W2560681683A5055418827 @default.
- W2560681683 hasAuthorship W2560681683A5055459949 @default.
- W2560681683 hasAuthorship W2560681683A5055833721 @default.
- W2560681683 hasAuthorship W2560681683A5061190003 @default.
- W2560681683 hasAuthorship W2560681683A5062068011 @default.
- W2560681683 hasAuthorship W2560681683A5069951920 @default.
- W2560681683 hasAuthorship W2560681683A5080931242 @default.
- W2560681683 hasAuthorship W2560681683A5087450860 @default.
- W2560681683 hasAuthorship W2560681683A5090005733 @default.
- W2560681683 hasAuthorship W2560681683A5091734086 @default.