FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560694811> ?p ?o ?g. }

• W2560694811 abstract "Proteomics have extended the list of high-density lipoprotein (HDL) associated proteins to about 90. One of the major issues of global protein characterization is establishing specificity of association as opposed to contamination, a fact which has never been addressed for isolated HDL. We have developed a refined purification strategy to isolate HDL by density, followed by purification by size to generate highly purified fractions of HDL2/3, which allow the reliable quantification of the HDL proteome for biomarker discovery. Mass spectrometry analysis revealed that the proteome of HDL2/3 is composed of 10-16 different proteins, which is in striking contrast to previous reports. Importantly, proteomic analysis revealed that many proteins which have recently been described to be associated with HDL, including α-1-antitrypsin, α-2-HS-glycoprotein, serotransferrin, apolipoprotein A-IV and others, are not associated with HDL2/3 and are exclusively found in a different molecular weight fraction containing human serum albumin, lipid-poor apolipoprotein A-I and other proteins. Interestingly, proteins found in this lower molecular weight fraction commonly share lipid-binding properties and enrichment of serum with free fatty acids/lysophophatidylcholine led to a significant increase in co-isolation of lipid-binding proteins such as albumin and α-1-antitrypsin. We propose that this refined method might become a standard in proteomic assessment of HDL2/3 making data from clinical cohorts more comparable and reproducible." @default.
• W2560694811 created "2016-12-16" @default.
• W2560694811 creator A5006321692 @default.
• W2560694811 creator A5025065985 @default.
• W2560694811 creator A5045112318 @default.
• W2560694811 creator A5065712472 @default.
• W2560694811 creator A5076744360 @default.
• W2560694811 creator A5082627239 @default.
• W2560694811 date "2016-12-01" @default.
• W2560694811 modified "2023-09-25" @default.
• W2560694811 title "Refined purification strategy for reliable proteomic profiling of HDL2/3: Impact on proteomic complexity" @default.
• W2560694811 cites W1650689119 @default.
• W2560694811 cites W1799915383 @default.
• W2560694811 cites W1964556269 @default.
• W2560694811 cites W1975586699 @default.
• W2560694811 cites W1989463629 @default.
• W2560694811 cites W2010588191 @default.
• W2560694811 cites W2015491565 @default.
• W2560694811 cites W2017654147 @default.
• W2560694811 cites W2036260862 @default.
• W2560694811 cites W2038792708 @default.
• W2560694811 cites W2046095066 @default.
• W2560694811 cites W2050185459 @default.
• W2560694811 cites W2052000579 @default.
• W2560694811 cites W2061100621 @default.
• W2560694811 cites W2071201425 @default.
• W2560694811 cites W2082119649 @default.
• W2560694811 cites W2083315579 @default.
• W2560694811 cites W2085228415 @default.
• W2560694811 cites W2128633067 @default.
• W2560694811 cites W2139976637 @default.
• W2560694811 cites W2140455131 @default.
• W2560694811 cites W2140480769 @default.
• W2560694811 cites W2145410077 @default.
• W2560694811 cites W2151280392 @default.
• W2560694811 cites W2165771284 @default.
• W2560694811 cites W2178833172 @default.
• W2560694811 cites W2218787476 @default.
• W2560694811 cites W2318365456 @default.
• W2560694811 cites W2444063973 @default.
• W2560694811 cites W2769328074 @default.
• W2560694811 cites W4233443627 @default.
• W2560694811 doi "https://doi.org/10.1038/srep38533" @default.
• W2560694811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5137140" @default.
• W2560694811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27917957" @default.
• W2560694811 hasPublicationYear "2016" @default.
• W2560694811 type Work @default.
• W2560694811 sameAs 2560694811 @default.
• W2560694811 citedByCount "31" @default.
• W2560694811 countsByYear W25606948112017 @default.
• W2560694811 countsByYear W25606948112018 @default.
• W2560694811 countsByYear W25606948112019 @default.
• W2560694811 countsByYear W25606948112020 @default.
• W2560694811 countsByYear W25606948112021 @default.
• W2560694811 countsByYear W25606948112022 @default.
• W2560694811 crossrefType "journal-article" @default.
• W2560694811 hasAuthorship W2560694811A5006321692 @default.
• W2560694811 hasAuthorship W2560694811A5025065985 @default.
• W2560694811 hasAuthorship W2560694811A5045112318 @default.
• W2560694811 hasAuthorship W2560694811A5065712472 @default.
• W2560694811 hasAuthorship W2560694811A5076744360 @default.
• W2560694811 hasAuthorship W2560694811A5082627239 @default.
• W2560694811 hasBestOaLocation W25606948111 @default.
• W2560694811 hasConcept C104317684 @default.
• W2560694811 hasConcept C104397665 @default.
• W2560694811 hasConcept C108625454 @default.
• W2560694811 hasConcept C124535831 @default.
• W2560694811 hasConcept C146543888 @default.
• W2560694811 hasConcept C185592680 @default.
• W2560694811 hasConcept C2776125364 @default.
• W2560694811 hasConcept C2778163477 @default.
• W2560694811 hasConcept C2780072125 @default.
• W2560694811 hasConcept C2780541478 @default.
• W2560694811 hasConcept C2780745583 @default.
• W2560694811 hasConcept C2781197716 @default.
• W2560694811 hasConcept C46111723 @default.
• W2560694811 hasConcept C55493867 @default.
• W2560694811 hasConcept C62746215 @default.
• W2560694811 hasConcept C70721500 @default.
• W2560694811 hasConcept C86803240 @default.
• W2560694811 hasConceptScore W2560694811C104317684 @default.
• W2560694811 hasConceptScore W2560694811C104397665 @default.
• W2560694811 hasConceptScore W2560694811C108625454 @default.
• W2560694811 hasConceptScore W2560694811C124535831 @default.
• W2560694811 hasConceptScore W2560694811C146543888 @default.
• W2560694811 hasConceptScore W2560694811C185592680 @default.
• W2560694811 hasConceptScore W2560694811C2776125364 @default.
• W2560694811 hasConceptScore W2560694811C2778163477 @default.
• W2560694811 hasConceptScore W2560694811C2780072125 @default.
• W2560694811 hasConceptScore W2560694811C2780541478 @default.
• W2560694811 hasConceptScore W2560694811C2780745583 @default.
• W2560694811 hasConceptScore W2560694811C2781197716 @default.
• W2560694811 hasConceptScore W2560694811C46111723 @default.
• W2560694811 hasConceptScore W2560694811C55493867 @default.
• W2560694811 hasConceptScore W2560694811C62746215 @default.
• W2560694811 hasConceptScore W2560694811C70721500 @default.
• W2560694811 hasConceptScore W2560694811C86803240 @default.
• W2560694811 hasIssue "1" @default.
• W2560694811 hasLocation W25606948111 @default.
• W2560694811 hasLocation W25606948112 @default.

• next