Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560699314> ?p ?o ?g. }
- W2560699314 endingPage "e0167768" @default.
- W2560699314 startingPage "e0167768" @default.
- W2560699314 abstract "Delonix regia (Boj. Ex. Hook) is a flowering plant in the pea family found in tropical areas and its leaves are used informally to treat diseases in folk medicine. However, the cardioprotective effects in this plant are still unclear. In this study, we found that the Delonix regia leaf extract (DRLE) (400 mg/kg/d) can reduce the mortality rate in an isoproterenol (ISO)-induced heart injury and hypertrophy mouse model. Decreased serum levels of creatine phosphokinase, LDH, GOT, TNF-alpha and increased nitric oxide levels were found in DRLE-treated ISO-injured mice. In the in vitro study, the porcine coronary artery exhibited vasodilation effect induced by DRLE in a dose-dependent manner. In the DRLE toxic test, overdose of DRLE showed the high safety in normal mice and may have the ability to remove the metabolic wastes in blood. In conclusion, we demonstrated for the first time that DRLE has the cardioprotective effects by activating the vasodilation through NO pathway and preventing the myocyte injury via inhibition of TNF-alpha pathway. We suggest that DRLE may act as a promising novel herbal medicine for cardioprotection." @default.
- W2560699314 created "2016-12-16" @default.
- W2560699314 creator A5016994638 @default.
- W2560699314 creator A5035372635 @default.
- W2560699314 creator A5038467125 @default.
- W2560699314 creator A5051316991 @default.
- W2560699314 creator A5078320657 @default.
- W2560699314 date "2016-12-09" @default.
- W2560699314 modified "2023-09-27" @default.
- W2560699314 title "Delonix regia Leaf Extract (DRLE): A Potential Therapeutic Agent for Cardioprotection" @default.
- W2560699314 cites W1521604813 @default.
- W2560699314 cites W1554926950 @default.
- W2560699314 cites W183096776 @default.
- W2560699314 cites W1916800720 @default.
- W2560699314 cites W1968236746 @default.
- W2560699314 cites W1978114446 @default.
- W2560699314 cites W1979904436 @default.
- W2560699314 cites W1982104587 @default.
- W2560699314 cites W1984870795 @default.
- W2560699314 cites W1986072191 @default.
- W2560699314 cites W1992010324 @default.
- W2560699314 cites W1993083361 @default.
- W2560699314 cites W2002439304 @default.
- W2560699314 cites W2013783974 @default.
- W2560699314 cites W2014732821 @default.
- W2560699314 cites W2021543924 @default.
- W2560699314 cites W2023064667 @default.
- W2560699314 cites W2024358105 @default.
- W2560699314 cites W2031206045 @default.
- W2560699314 cites W2051645126 @default.
- W2560699314 cites W2053164321 @default.
- W2560699314 cites W2056865510 @default.
- W2560699314 cites W2056892039 @default.
- W2560699314 cites W2057279220 @default.
- W2560699314 cites W2059204180 @default.
- W2560699314 cites W2077970983 @default.
- W2560699314 cites W2078166953 @default.
- W2560699314 cites W2081904176 @default.
- W2560699314 cites W2085349263 @default.
- W2560699314 cites W2088744215 @default.
- W2560699314 cites W2089614120 @default.
- W2560699314 cites W2092476798 @default.
- W2560699314 cites W2093911645 @default.
- W2560699314 cites W2094545133 @default.
- W2560699314 cites W2095043800 @default.
- W2560699314 cites W2103459618 @default.
- W2560699314 cites W2109182862 @default.
- W2560699314 cites W2118236312 @default.
- W2560699314 cites W2119548032 @default.
- W2560699314 cites W2123399057 @default.
- W2560699314 cites W2126247761 @default.
- W2560699314 cites W2137042507 @default.
- W2560699314 cites W2147649093 @default.
- W2560699314 cites W2157120390 @default.
- W2560699314 cites W2157944478 @default.
- W2560699314 cites W2167152104 @default.
- W2560699314 cites W2167200363 @default.
- W2560699314 cites W2168767422 @default.
- W2560699314 cites W2188292605 @default.
- W2560699314 cites W2291089987 @default.
- W2560699314 cites W2321309958 @default.
- W2560699314 doi "https://doi.org/10.1371/journal.pone.0167768" @default.
- W2560699314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5147973" @default.
- W2560699314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27936072" @default.
- W2560699314 hasPublicationYear "2016" @default.
- W2560699314 type Work @default.
- W2560699314 sameAs 2560699314 @default.
- W2560699314 citedByCount "9" @default.
- W2560699314 countsByYear W25606993142018 @default.
- W2560699314 countsByYear W25606993142020 @default.
- W2560699314 countsByYear W25606993142021 @default.
- W2560699314 countsByYear W25606993142022 @default.
- W2560699314 countsByYear W25606993142023 @default.
- W2560699314 crossrefType "journal-article" @default.
- W2560699314 hasAuthorship W2560699314A5016994638 @default.
- W2560699314 hasAuthorship W2560699314A5035372635 @default.
- W2560699314 hasAuthorship W2560699314A5038467125 @default.
- W2560699314 hasAuthorship W2560699314A5051316991 @default.
- W2560699314 hasAuthorship W2560699314A5078320657 @default.
- W2560699314 hasBestOaLocation W25606993141 @default.
- W2560699314 hasConcept C120770815 @default.
- W2560699314 hasConcept C126322002 @default.
- W2560699314 hasConcept C2779676291 @default.
- W2560699314 hasConcept C36880943 @default.
- W2560699314 hasConcept C500558357 @default.
- W2560699314 hasConcept C519581460 @default.
- W2560699314 hasConcept C556039675 @default.
- W2560699314 hasConcept C71924100 @default.
- W2560699314 hasConcept C98274493 @default.
- W2560699314 hasConceptScore W2560699314C120770815 @default.
- W2560699314 hasConceptScore W2560699314C126322002 @default.
- W2560699314 hasConceptScore W2560699314C2779676291 @default.
- W2560699314 hasConceptScore W2560699314C36880943 @default.
- W2560699314 hasConceptScore W2560699314C500558357 @default.
- W2560699314 hasConceptScore W2560699314C519581460 @default.
- W2560699314 hasConceptScore W2560699314C556039675 @default.
- W2560699314 hasConceptScore W2560699314C71924100 @default.
- W2560699314 hasConceptScore W2560699314C98274493 @default.