FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560705106> ?p ?o ?g. }

• W2560705106 endingPage "374" @default.
• W2560705106 startingPage "366" @default.
• W2560705106 abstract "Sepsis often causes diaphragm contractile dysfunction. Endoplasmic reticulum (ER) stress has been implicated in muscle contractile dysfunction. However, it remains unknown if ER stress occurs in the diaphragm during sepsis. In the present study, rats were divided into 4 groups and received placebo or one of three durations of endotoxin treatment (24, 48 h and 7 days). Isometric contractile force of the diaphragm was measured and lung wet-to-dry ratio (W/D) was calculated. Hematoxylin and eosin (H&E) staining of lung tissue was performed and electron microscopy assessed ER damage in the diaphragm during sepsis. The mRNA and protein expression of glucose‑regulated protein 78 kDa (GRP78), glucose-regulated protein 94 kDa (GRP94), C/EBP homologous protein (CHOP), endoplasmic reticulum protein 44 (ERP44), protein disulfide-isomerase like protein (ERP57) and protein disulfide isomerase family A member 4 (ERP72) in diaphragm muscles were measured using reverse transcription‑quantitative polymerase chain reaction and western blot analysis. The level of cleaved caspase-12 was analyzed by western blot analysis. The results demonstrated that sepsis increased lung W/D. H&E staining revealed that sepsis caused alveolar congestion, hemorrhage and rupture. Swollen and distended ER was observed using electron microscopy during sepsis and decreased diaphragm contractile function was also observed. The expression levels of ER stress markers (GRP78, GRP94, CHOP, ERP44, ERP57 and ERP72) and the level of cleaved caspase‑12 were significantly elevated in septic rats compared with control rats, particularly in the 48 h group. In conclusion, the present study indicated that weakened diaphragm contraction and damaged ER in septic rats was associated with increased expression of ER stress markers." @default.
• W2560705106 created "2016-12-16" @default.
• W2560705106 creator A5001708890 @default.
• W2560705106 creator A5018554791 @default.
• W2560705106 creator A5031374841 @default.
• W2560705106 creator A5046865893 @default.
• W2560705106 creator A5049732456 @default.
• W2560705106 creator A5051035910 @default.
• W2560705106 creator A5061937337 @default.
• W2560705106 creator A5069522797 @default.
• W2560705106 creator A5069542752 @default.
• W2560705106 creator A5075785492 @default.
• W2560705106 date "2016-12-09" @default.
• W2560705106 modified "2023-10-13" @default.
• W2560705106 title "Upregulation of endoplasmic reticulum stress is associated with diaphragm contractile dysfunction in a rat model of sepsis" @default.
• W2560705106 cites W1482228598 @default.
• W2560705106 cites W1602313315 @default.
• W2560705106 cites W1608262088 @default.
• W2560705106 cites W1965070759 @default.
• W2560705106 cites W1971895086 @default.
• W2560705106 cites W1976679648 @default.
• W2560705106 cites W1977321095 @default.
• W2560705106 cites W1988262777 @default.
• W2560705106 cites W1988718057 @default.
• W2560705106 cites W1990817996 @default.
• W2560705106 cites W1994734638 @default.
• W2560705106 cites W1999649561 @default.
• W2560705106 cites W2010063380 @default.
• W2560705106 cites W2019221767 @default.
• W2560705106 cites W2028508399 @default.
• W2560705106 cites W2029642537 @default.
• W2560705106 cites W2031591517 @default.
• W2560705106 cites W2034213169 @default.
• W2560705106 cites W2034305215 @default.
• W2560705106 cites W2039712051 @default.
• W2560705106 cites W2065843842 @default.
• W2560705106 cites W2067246993 @default.
• W2560705106 cites W2075646810 @default.
• W2560705106 cites W2089198803 @default.
• W2560705106 cites W2094381745 @default.
• W2560705106 cites W2101720048 @default.
• W2560705106 cites W2107277218 @default.
• W2560705106 cites W2113535256 @default.
• W2560705106 cites W2122103893 @default.
• W2560705106 cites W2122795906 @default.
• W2560705106 cites W2124190061 @default.
• W2560705106 cites W2133762721 @default.
• W2560705106 cites W2137755719 @default.
• W2560705106 cites W2138193104 @default.
• W2560705106 cites W2141156437 @default.
• W2560705106 cites W2142255702 @default.
• W2560705106 cites W2148632242 @default.
• W2560705106 cites W2157740989 @default.
• W2560705106 cites W2157900120 @default.
• W2560705106 cites W2158843717 @default.
• W2560705106 cites W2162349906 @default.
• W2560705106 cites W2166019746 @default.
• W2560705106 cites W2169299508 @default.
• W2560705106 cites W2169404909 @default.
• W2560705106 cites W2345930487 @default.
• W2560705106 cites W2400287488 @default.
• W2560705106 cites W2400936627 @default.
• W2560705106 cites W2418662167 @default.
• W2560705106 cites W86932206 @default.
• W2560705106 doi "https://doi.org/10.3892/mmr.2016.6014" @default.
• W2560705106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27959404" @default.
• W2560705106 hasPublicationYear "2016" @default.
• W2560705106 type Work @default.
• W2560705106 sameAs 2560705106 @default.
• W2560705106 citedByCount "21" @default.
• W2560705106 countsByYear W25607051062017 @default.
• W2560705106 countsByYear W25607051062019 @default.
• W2560705106 countsByYear W25607051062020 @default.
• W2560705106 countsByYear W25607051062021 @default.
• W2560705106 countsByYear W25607051062022 @default.
• W2560705106 countsByYear W25607051062023 @default.
• W2560705106 crossrefType "journal-article" @default.
• W2560705106 hasAuthorship W2560705106A5001708890 @default.
• W2560705106 hasAuthorship W2560705106A5018554791 @default.
• W2560705106 hasAuthorship W2560705106A5031374841 @default.
• W2560705106 hasAuthorship W2560705106A5046865893 @default.
• W2560705106 hasAuthorship W2560705106A5049732456 @default.
• W2560705106 hasAuthorship W2560705106A5051035910 @default.
• W2560705106 hasAuthorship W2560705106A5061937337 @default.
• W2560705106 hasAuthorship W2560705106A5069522797 @default.
• W2560705106 hasAuthorship W2560705106A5069542752 @default.
• W2560705106 hasAuthorship W2560705106A5075785492 @default.
• W2560705106 hasBestOaLocation W25607051061 @default.
• W2560705106 hasConcept C104317684 @default.
• W2560705106 hasConcept C126322002 @default.
• W2560705106 hasConcept C127561419 @default.
• W2560705106 hasConcept C134018914 @default.
• W2560705106 hasConcept C139447449 @default.
• W2560705106 hasConcept C158617107 @default.
• W2560705106 hasConcept C2776415932 @default.
• W2560705106 hasConcept C2778384902 @default.
• W2560705106 hasConcept C5098756 @default.
• W2560705106 hasConcept C55493867 @default.

• next