FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560712388> ?p ?o ?g. }

• W2560712388 endingPage "8" @default.
• W2560712388 startingPage "1" @default.
• W2560712388 abstract "It has been observed by in vivo imaging that damaged neuronal structures can be reversibly restored after ischemic insults with the application of timely therapeutic interventions. However, what degree of neuronal damage can be restored and the time frame for reversible recovery of neuronal structures remain unclear. Here, transcranial two-photon imaging, histological staining and electron microscopy were used to investigate the reversible recovery of neuronal structures from dendrites to soma after different durations of global cerebral ischemia in mice. Intravital imaging revealed that the damage to dendritic structures was reversible when ischemia time was <1h, but they became difficult to restore after >3h of ischemia. Data from fixed YFP brain slice and Golgi staining indicated that the damage of dendritic structures progressively extended to deeper dendritic shafts with the extension of ischemia time. Furthermore, longer duration of ischemia caused an increasing number of degenerating neurons. Importantly, significant chromatin margination and karyopyknosis of neuron were observed after 6h of ischemia. These data suggested that neuronal structures could be reversibly restored when ischemia time was <1h, but irreversible and progressive damage to neurons occurred with longer duration of ischemia. Consistently, behavioral performance of post-ischemic animals experienced an ischemia time-dependent recovery. Taken together, our data suggested that recovery of neuronal structures following ischemia was dependent on the duration of ischemia, and prevention of neuronal loss is a key target for therapeutic interventions in ischemic stroke." @default.
• W2560712388 created "2016-12-16" @default.
• W2560712388 creator A5013212956 @default.
• W2560712388 creator A5025439445 @default.
• W2560712388 creator A5052766959 @default.
• W2560712388 creator A5066496211 @default.
• W2560712388 creator A5073216396 @default.
• W2560712388 creator A5078294650 @default.
• W2560712388 date "2017-03-01" @default.
• W2560712388 modified "2023-10-18" @default.
• W2560712388 title "Reversible recovery of neuronal structures depends on the degree of neuronal damage after global cerebral ischemia in mice" @default.
• W2560712388 cites W1482293895 @default.
• W2560712388 cites W1919929830 @default.
• W2560712388 cites W1963892835 @default.
• W2560712388 cites W1984131513 @default.
• W2560712388 cites W1984664722 @default.
• W2560712388 cites W1986782185 @default.
• W2560712388 cites W1989483418 @default.
• W2560712388 cites W1989718007 @default.
• W2560712388 cites W1993220836 @default.
• W2560712388 cites W2004976934 @default.
• W2560712388 cites W2005500002 @default.
• W2560712388 cites W2015341417 @default.
• W2560712388 cites W2016212019 @default.
• W2560712388 cites W2018773565 @default.
• W2560712388 cites W2025507126 @default.
• W2560712388 cites W2026460828 @default.
• W2560712388 cites W2028496416 @default.
• W2560712388 cites W2034376984 @default.
• W2560712388 cites W2036472881 @default.
• W2560712388 cites W2038055601 @default.
• W2560712388 cites W2046257967 @default.
• W2560712388 cites W2046573605 @default.
• W2560712388 cites W2052853635 @default.
• W2560712388 cites W2055795947 @default.
• W2560712388 cites W2057332354 @default.
• W2560712388 cites W2062208243 @default.
• W2560712388 cites W2071957609 @default.
• W2560712388 cites W2078170139 @default.
• W2560712388 cites W2084609653 @default.
• W2560712388 cites W2102828922 @default.
• W2560712388 cites W2103762808 @default.
• W2560712388 cites W2106195770 @default.
• W2560712388 cites W2154840243 @default.
• W2560712388 cites W2159233098 @default.
• W2560712388 cites W2161059964 @default.
• W2560712388 cites W2163217967 @default.
• W2560712388 cites W2407930161 @default.
• W2560712388 doi "https://doi.org/10.1016/j.expneurol.2016.12.002" @default.
• W2560712388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27940018" @default.
• W2560712388 hasPublicationYear "2017" @default.
• W2560712388 type Work @default.
• W2560712388 sameAs 2560712388 @default.
• W2560712388 citedByCount "23" @default.
• W2560712388 countsByYear W25607123882018 @default.
• W2560712388 countsByYear W25607123882020 @default.
• W2560712388 countsByYear W25607123882021 @default.
• W2560712388 countsByYear W25607123882022 @default.
• W2560712388 countsByYear W25607123882023 @default.
• W2560712388 crossrefType "journal-article" @default.
• W2560712388 hasAuthorship W2560712388A5013212956 @default.
• W2560712388 hasAuthorship W2560712388A5025439445 @default.
• W2560712388 hasAuthorship W2560712388A5052766959 @default.
• W2560712388 hasAuthorship W2560712388A5066496211 @default.
• W2560712388 hasAuthorship W2560712388A5073216396 @default.
• W2560712388 hasAuthorship W2560712388A5078294650 @default.
• W2560712388 hasConcept C126322002 @default.
• W2560712388 hasConcept C150903083 @default.
• W2560712388 hasConcept C169760540 @default.
• W2560712388 hasConcept C207001950 @default.
• W2560712388 hasConcept C2778794669 @default.
• W2560712388 hasConcept C2778820722 @default.
• W2560712388 hasConcept C2779617337 @default.
• W2560712388 hasConcept C541997718 @default.
• W2560712388 hasConcept C71924100 @default.
• W2560712388 hasConcept C86803240 @default.
• W2560712388 hasConceptScore W2560712388C126322002 @default.
• W2560712388 hasConceptScore W2560712388C150903083 @default.
• W2560712388 hasConceptScore W2560712388C169760540 @default.
• W2560712388 hasConceptScore W2560712388C207001950 @default.
• W2560712388 hasConceptScore W2560712388C2778794669 @default.
• W2560712388 hasConceptScore W2560712388C2778820722 @default.
• W2560712388 hasConceptScore W2560712388C2779617337 @default.
• W2560712388 hasConceptScore W2560712388C541997718 @default.
• W2560712388 hasConceptScore W2560712388C71924100 @default.
• W2560712388 hasConceptScore W2560712388C86803240 @default.
• W2560712388 hasFunder F4320321001 @default.
• W2560712388 hasFunder F4320336024 @default.
• W2560712388 hasLocation W25607123881 @default.
• W2560712388 hasLocation W25607123882 @default.
• W2560712388 hasOpenAccess W2560712388 @default.
• W2560712388 hasPrimaryLocation W25607123881 @default.
• W2560712388 hasRelatedWork W1987439527 @default.
• W2560712388 hasRelatedWork W1992691074 @default.
• W2560712388 hasRelatedWork W2043103177 @default.
• W2560712388 hasRelatedWork W2056677259 @default.
• W2560712388 hasRelatedWork W2065916848 @default.
• W2560712388 hasRelatedWork W2163204327 @default.

• next