Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560714593> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2560714593 abstract "Background In Huntington’s disease (HD), there is neuronal loss in distributed brain regions predominating in the basal ganglia but also present in the cortex. Functional imaging studies at rest have reported reduced long-range functional connectivity within motor areas as well as associative areas of the frontal and parietal lobes, the basal ganglia and the default mode network. Changes in functional connectivity over time in longitudinal studies in HD and preHD is less known although two studies did not find significant changes in connectivity over one- to three-year periods. Aims We evaluated the changes in functional organisation within the sensorimotor, associative and limbic cortico-basal ganglia networks in preHD and HD patients compared with controls using resting-state fMRI (rs-fMRI) and graph theory over a two-year period. Methods We acquired structural MRI and rs-fMRI in three visits one year apart, in 18 adult HD patients, 24 preHD and 18 gender- and age-matched healthy volunteers from the TRACK-HD study. We inferred topological changes in functional connectivity between 182 regions within cortico-basal ganglia networks using graph theory measures. Results We found significant differences for global graph theory measures in HD but not in preHD. The average shortest path length (L) decreased, which indicated a change toward the random network topology. HD patients also demonstrated increases in degree k, reduced betweeness centrality bc and reduced clustering C. Changes predominated in the sensorimotor network for bc and C and were observed in all circuits for k. Hubs were reduced in preHD and no longer detectable in HD in the sensorimotor and associative networks. Conclusion PreHD is characterised by progressive decrease in hub organisation, and these changes aggravate in HD patients with changes in local metrics." @default.
- W2560714593 created "2016-12-16" @default.
- W2560714593 creator A5027293126 @default.
- W2560714593 creator A5029597969 @default.
- W2560714593 creator A5030684365 @default.
- W2560714593 creator A5031967892 @default.
- W2560714593 creator A5035205639 @default.
- W2560714593 creator A5041885603 @default.
- W2560714593 creator A5050634458 @default.
- W2560714593 creator A5064275363 @default.
- W2560714593 creator A5065401900 @default.
- W2560714593 creator A5076164549 @default.
- W2560714593 creator A5081095787 @default.
- W2560714593 creator A5090830124 @default.
- W2560714593 date "2016-09-01" @default.
- W2560714593 modified "2023-10-17" @default.
- W2560714593 title "D19 Longitudinal changes in functional connectivity of cortico-basal ganglia networks in manifest and premanifest huntington’s disease" @default.
- W2560714593 cites W1179800764 @default.
- W2560714593 doi "https://doi.org/10.1136/jnnp-2016-314597.118" @default.
- W2560714593 hasPublicationYear "2016" @default.
- W2560714593 type Work @default.
- W2560714593 sameAs 2560714593 @default.
- W2560714593 citedByCount "0" @default.
- W2560714593 crossrefType "journal-article" @default.
- W2560714593 hasAuthorship W2560714593A5027293126 @default.
- W2560714593 hasAuthorship W2560714593A5029597969 @default.
- W2560714593 hasAuthorship W2560714593A5030684365 @default.
- W2560714593 hasAuthorship W2560714593A5031967892 @default.
- W2560714593 hasAuthorship W2560714593A5035205639 @default.
- W2560714593 hasAuthorship W2560714593A5041885603 @default.
- W2560714593 hasAuthorship W2560714593A5050634458 @default.
- W2560714593 hasAuthorship W2560714593A5064275363 @default.
- W2560714593 hasAuthorship W2560714593A5065401900 @default.
- W2560714593 hasAuthorship W2560714593A5076164549 @default.
- W2560714593 hasAuthorship W2560714593A5081095787 @default.
- W2560714593 hasAuthorship W2560714593A5090830124 @default.
- W2560714593 hasConcept C126322002 @default.
- W2560714593 hasConcept C141516989 @default.
- W2560714593 hasConcept C15744967 @default.
- W2560714593 hasConcept C169760540 @default.
- W2560714593 hasConcept C2778187257 @default.
- W2560714593 hasConcept C2779134260 @default.
- W2560714593 hasConcept C2780647506 @default.
- W2560714593 hasConcept C3018011982 @default.
- W2560714593 hasConcept C529278444 @default.
- W2560714593 hasConcept C66324658 @default.
- W2560714593 hasConcept C71924100 @default.
- W2560714593 hasConceptScore W2560714593C126322002 @default.
- W2560714593 hasConceptScore W2560714593C141516989 @default.
- W2560714593 hasConceptScore W2560714593C15744967 @default.
- W2560714593 hasConceptScore W2560714593C169760540 @default.
- W2560714593 hasConceptScore W2560714593C2778187257 @default.
- W2560714593 hasConceptScore W2560714593C2779134260 @default.
- W2560714593 hasConceptScore W2560714593C2780647506 @default.
- W2560714593 hasConceptScore W2560714593C3018011982 @default.
- W2560714593 hasConceptScore W2560714593C529278444 @default.
- W2560714593 hasConceptScore W2560714593C66324658 @default.
- W2560714593 hasConceptScore W2560714593C71924100 @default.
- W2560714593 hasLocation W25607145931 @default.
- W2560714593 hasOpenAccess W2560714593 @default.
- W2560714593 hasPrimaryLocation W25607145931 @default.
- W2560714593 hasRelatedWork W1910980175 @default.
- W2560714593 hasRelatedWork W1966491155 @default.
- W2560714593 hasRelatedWork W1974371179 @default.
- W2560714593 hasRelatedWork W2000561294 @default.
- W2560714593 hasRelatedWork W2024954481 @default.
- W2560714593 hasRelatedWork W2033431866 @default.
- W2560714593 hasRelatedWork W2238160627 @default.
- W2560714593 hasRelatedWork W2320563818 @default.
- W2560714593 hasRelatedWork W2328523822 @default.
- W2560714593 hasRelatedWork W2332438073 @default.
- W2560714593 hasRelatedWork W2559894468 @default.
- W2560714593 hasRelatedWork W2560255765 @default.
- W2560714593 hasRelatedWork W2560480805 @default.
- W2560714593 hasRelatedWork W2762686566 @default.
- W2560714593 hasRelatedWork W2765428055 @default.
- W2560714593 hasRelatedWork W2907375349 @default.
- W2560714593 hasRelatedWork W2968859363 @default.
- W2560714593 hasRelatedWork W2982197545 @default.
- W2560714593 hasRelatedWork W3081623308 @default.
- W2560714593 hasRelatedWork W3129823510 @default.
- W2560714593 isParatext "false" @default.
- W2560714593 isRetracted "false" @default.
- W2560714593 magId "2560714593" @default.
- W2560714593 workType "article" @default.