Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560731570> ?p ?o ?g. }
- W2560731570 endingPage "134" @default.
- W2560731570 startingPage "119" @default.
- W2560731570 abstract "Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous disease with no effective treatment. Drug development has been hampered by the lack of biomarkers that aid in early diagnosis, demonstrate target engagement, monitor disease progression, and can serve as surrogate endpoints to assess the efficacy of treatments. Fluid-based biomarkers may potentially address these issues. An ideal biomarker should exhibit high specificity and sensitivity for distinguishing ALS from control (appropriate disease mimics and other neurologic diseases) populations and monitor disease progression within individual patients. Significant progress has been made using cerebrospinal fluid, serum, and plasma in the search for ALS biomarkers, with urine and saliva biomarkers still in earlier stages of development. A few of these biomarker candidates have demonstrated use in patient stratification, predicting disease course (fast vs slow progression) and severity, or have been used in preclinical and clinical applications. However, while ALS biomarker discovery has seen tremendous advancements in the last decade, validating biomarkers and moving them towards the clinic remains more elusive. In this review, we highlight biomarkers that are moving towards clinical utility and the challenges that remain in order to implement biomarkers at all stages of the ALS drug development process." @default.
- W2560731570 created "2016-12-16" @default.
- W2560731570 creator A5013183295 @default.
- W2560731570 creator A5057092035 @default.
- W2560731570 date "2016-12-08" @default.
- W2560731570 modified "2023-10-12" @default.
- W2560731570 title "Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis" @default.
- W2560731570 cites W144423133 @default.
- W2560731570 cites W1480524493 @default.
- W2560731570 cites W1533089316 @default.
- W2560731570 cites W1539762804 @default.
- W2560731570 cites W1545634912 @default.
- W2560731570 cites W1558795029 @default.
- W2560731570 cites W159408179 @default.
- W2560731570 cites W1610732998 @default.
- W2560731570 cites W1708297083 @default.
- W2560731570 cites W1856124239 @default.
- W2560731570 cites W1927582128 @default.
- W2560731570 cites W1941480039 @default.
- W2560731570 cites W1955522487 @default.
- W2560731570 cites W1965302033 @default.
- W2560731570 cites W1965434700 @default.
- W2560731570 cites W1971606140 @default.
- W2560731570 cites W1972395654 @default.
- W2560731570 cites W1976266513 @default.
- W2560731570 cites W1977390583 @default.
- W2560731570 cites W1981929653 @default.
- W2560731570 cites W1984538960 @default.
- W2560731570 cites W1985582661 @default.
- W2560731570 cites W1986176703 @default.
- W2560731570 cites W1987066016 @default.
- W2560731570 cites W1988931872 @default.
- W2560731570 cites W1989464571 @default.
- W2560731570 cites W1991117617 @default.
- W2560731570 cites W1991972100 @default.
- W2560731570 cites W1992768136 @default.
- W2560731570 cites W2000125318 @default.
- W2560731570 cites W2002057564 @default.
- W2560731570 cites W2002071227 @default.
- W2560731570 cites W2003618511 @default.
- W2560731570 cites W2007568107 @default.
- W2560731570 cites W2011007124 @default.
- W2560731570 cites W2011575330 @default.
- W2560731570 cites W2011875602 @default.
- W2560731570 cites W2012662246 @default.
- W2560731570 cites W2012739537 @default.
- W2560731570 cites W2013154697 @default.
- W2560731570 cites W2015037203 @default.
- W2560731570 cites W2016951305 @default.
- W2560731570 cites W2022375226 @default.
- W2560731570 cites W2023312191 @default.
- W2560731570 cites W2023567967 @default.
- W2560731570 cites W2024118360 @default.
- W2560731570 cites W2026158140 @default.
- W2560731570 cites W2026863482 @default.
- W2560731570 cites W2028768619 @default.
- W2560731570 cites W2029678309 @default.
- W2560731570 cites W2030932792 @default.
- W2560731570 cites W2031964319 @default.
- W2560731570 cites W2032384212 @default.
- W2560731570 cites W2032629617 @default.
- W2560731570 cites W2033797433 @default.
- W2560731570 cites W2035357370 @default.
- W2560731570 cites W2040316493 @default.
- W2560731570 cites W2044604766 @default.
- W2560731570 cites W2046180421 @default.
- W2560731570 cites W2047018448 @default.
- W2560731570 cites W2049175617 @default.
- W2560731570 cites W2052542747 @default.
- W2560731570 cites W2052578428 @default.
- W2560731570 cites W2058688785 @default.
- W2560731570 cites W2059977526 @default.
- W2560731570 cites W2060163046 @default.
- W2560731570 cites W2060812039 @default.
- W2560731570 cites W2060876918 @default.
- W2560731570 cites W2061245056 @default.
- W2560731570 cites W2062810043 @default.
- W2560731570 cites W2062890651 @default.
- W2560731570 cites W2063028213 @default.
- W2560731570 cites W2063896948 @default.
- W2560731570 cites W2067350758 @default.
- W2560731570 cites W2069171272 @default.
- W2560731570 cites W2069523418 @default.
- W2560731570 cites W2071434138 @default.
- W2560731570 cites W2071921711 @default.
- W2560731570 cites W2073649666 @default.
- W2560731570 cites W2073864172 @default.
- W2560731570 cites W2074177440 @default.
- W2560731570 cites W2074715310 @default.
- W2560731570 cites W2075416033 @default.
- W2560731570 cites W2076253751 @default.
- W2560731570 cites W2076495609 @default.
- W2560731570 cites W2076745180 @default.
- W2560731570 cites W2078220958 @default.
- W2560731570 cites W2083270026 @default.
- W2560731570 cites W2084634452 @default.
- W2560731570 cites W2085165928 @default.
- W2560731570 cites W2085705498 @default.