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- W2560763458 endingPage "e5546" @default.
- W2560763458 startingPage "e5546" @default.
- W2560763458 abstract "The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains undetermined.Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of β-catenin expression and patients' clinicopathological features or prognosis was analyzed.Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that β-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08-2.10]) or reduced expression of β-catenin in the membrane (HR: 1.33[95% CI: 1.15-1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of β-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85-1.18]) did not show significant association with 5-year OS.This study suggested that β-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results." @default.
- W2560763458 created "2016-12-16" @default.
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- W2560763458 date "2016-12-01" @default.
- W2560763458 modified "2023-09-23" @default.
- W2560763458 title "Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma" @default.
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- W2560763458 doi "https://doi.org/10.1097/md.0000000000005546" @default.
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