Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560778142> ?p ?o ?g. }
- W2560778142 endingPage "776" @default.
- W2560778142 startingPage "770" @default.
- W2560778142 abstract "The interleukin (IL)-17/IL-17 receptor (IL-17R) complex has been shown to be important for the regulation of inflammation; however, its role in the regulation of tumor processes has recently emerged as a research focus. The present study demonstrated that oxaliplatin was able to increase the levels of IL‑17/IL‑17R in hepatocellular carcinoma (HCC) patients and cells lines, and that it had important roles in reducing the susceptibility of the cells to oxaliplatin‑induced apoptosis. Furthermore, the expression of autophagy‑related proteins was induced by IL-17/IL-17R and autophagy was shown to induce resistance to oxaliplatin in HCC. In addition, the janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway was shown to be an important pathway in the induction of autophagy in response to oxaliplatin. Autopjhagy was inhibited by 3-methyladenine and JAK2/STAT3 signaling was blocked by AG490, which induced apoptosis in SMMC7721 cells treated with oxaliplatin. The results of the present study may help to elucidate the mechanism underlying the role of IL‑17/IL‑17R‑induced autophagy in the chemoresistance of HCC, as well as help to establish and develop measures to overcome chemoresistance in HCC." @default.
- W2560778142 created "2016-12-16" @default.
- W2560778142 creator A5001077267 @default.
- W2560778142 creator A5023907849 @default.
- W2560778142 creator A5029667848 @default.
- W2560778142 creator A5049575292 @default.
- W2560778142 creator A5060185042 @default.
- W2560778142 creator A5071175772 @default.
- W2560778142 creator A5082823078 @default.
- W2560778142 date "2016-12-08" @default.
- W2560778142 modified "2023-10-11" @default.
- W2560778142 title "Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway" @default.
- W2560778142 cites W1553446143 @default.
- W2560778142 cites W1570471712 @default.
- W2560778142 cites W1579017906 @default.
- W2560778142 cites W1603052847 @default.
- W2560778142 cites W1896849962 @default.
- W2560778142 cites W1966768211 @default.
- W2560778142 cites W1971113195 @default.
- W2560778142 cites W1971700041 @default.
- W2560778142 cites W1975204978 @default.
- W2560778142 cites W1976232839 @default.
- W2560778142 cites W1977767269 @default.
- W2560778142 cites W1978991749 @default.
- W2560778142 cites W1990461493 @default.
- W2560778142 cites W1994279450 @default.
- W2560778142 cites W2002196794 @default.
- W2560778142 cites W2004734814 @default.
- W2560778142 cites W2006252261 @default.
- W2560778142 cites W2009438958 @default.
- W2560778142 cites W2016491270 @default.
- W2560778142 cites W2017987372 @default.
- W2560778142 cites W2018820040 @default.
- W2560778142 cites W2020233428 @default.
- W2560778142 cites W2020340498 @default.
- W2560778142 cites W2020344969 @default.
- W2560778142 cites W2020912000 @default.
- W2560778142 cites W2021630989 @default.
- W2560778142 cites W2024628230 @default.
- W2560778142 cites W2027949856 @default.
- W2560778142 cites W2030986617 @default.
- W2560778142 cites W2033893737 @default.
- W2560778142 cites W2034198209 @default.
- W2560778142 cites W2036012609 @default.
- W2560778142 cites W2045758206 @default.
- W2560778142 cites W2049173806 @default.
- W2560778142 cites W2073441708 @default.
- W2560778142 cites W2077842353 @default.
- W2560778142 cites W2082355038 @default.
- W2560778142 cites W2087658241 @default.
- W2560778142 cites W2098812016 @default.
- W2560778142 cites W2102073216 @default.
- W2560778142 cites W2102647655 @default.
- W2560778142 cites W2103366137 @default.
- W2560778142 cites W2106255061 @default.
- W2560778142 cites W2108835820 @default.
- W2560778142 cites W2115752847 @default.
- W2560778142 cites W2118901014 @default.
- W2560778142 cites W2140373863 @default.
- W2560778142 cites W2149003918 @default.
- W2560778142 cites W2155881038 @default.
- W2560778142 cites W2163243653 @default.
- W2560778142 cites W2166609587 @default.
- W2560778142 cites W2170394385 @default.
- W2560778142 cites W2331679160 @default.
- W2560778142 cites W2344304967 @default.
- W2560778142 cites W2524344035 @default.
- W2560778142 cites W2533437794 @default.
- W2560778142 cites W2536940559 @default.
- W2560778142 cites W2542685069 @default.
- W2560778142 cites W2743254891 @default.
- W2560778142 cites W2995442355 @default.
- W2560778142 cites W89255747 @default.
- W2560778142 cites W2195531534 @default.
- W2560778142 doi "https://doi.org/10.3892/ol.2016.5476" @default.
- W2560778142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5351189" @default.
- W2560778142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28356957" @default.
- W2560778142 hasPublicationYear "2016" @default.
- W2560778142 type Work @default.
- W2560778142 sameAs 2560778142 @default.
- W2560778142 citedByCount "28" @default.
- W2560778142 countsByYear W25607781422017 @default.
- W2560778142 countsByYear W25607781422018 @default.
- W2560778142 countsByYear W25607781422019 @default.
- W2560778142 countsByYear W25607781422020 @default.
- W2560778142 countsByYear W25607781422021 @default.
- W2560778142 countsByYear W25607781422022 @default.
- W2560778142 countsByYear W25607781422023 @default.
- W2560778142 crossrefType "journal-article" @default.
- W2560778142 hasAuthorship W2560778142A5001077267 @default.
- W2560778142 hasAuthorship W2560778142A5023907849 @default.
- W2560778142 hasAuthorship W2560778142A5029667848 @default.
- W2560778142 hasAuthorship W2560778142A5049575292 @default.
- W2560778142 hasAuthorship W2560778142A5060185042 @default.
- W2560778142 hasAuthorship W2560778142A5071175772 @default.
- W2560778142 hasAuthorship W2560778142A5082823078 @default.
- W2560778142 hasBestOaLocation W25607781421 @default.
- W2560778142 hasConcept C112392421 @default.