FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560791331> ?p ?o ?g. }

• W2560791331 endingPage "e973" @default.
• W2560791331 startingPage "e973" @default.
• W2560791331 abstract "Abstract Patients with Alzheimer’s disease (AD), a common dementia among the aging population, often also suffer from depression. This comorbidity is poorly understood. Although most forms of AD are not genetically inherited, we have identified a new human mutation in the carboxypeptidase E (CPE)/neurotrophic factor-α1 (NF-α1) gene from an AD patient that caused memory deficit and depressive-like behavior in transgenic mice. This mutation consists of three adenosine inserts, introducing nine amino acids, including two glutamines into the mutant protein, herein called CPE-QQ. Expression of CPE-QQ in Neuro2a cells demonstrated that it was not secreted, but accumulated in the endoplasmic reticulum and was subsequently degraded by proteasomes. Expression of CPE-QQ in rat hippocampal neurons resulted in cell death, through increased ER stress and decreased expression of pro-survival protein, BCL-2. Transgenic mice expressing CPE-QQ did not show any difference in the processing enzyme activity of CPE compared with wild-type mice. However, the transgenic mice exhibited poor memory, depressive-like behavior, severely decreased dendrites in the hippocampal CA3 region and medial prefrontal cortex indicative of neurodegeneration, hyperphosphorylation of tau at Ser 396 , and diminished neurogenesis in the dentate gyrus at 50 weeks old. All these pathologies are associated with AD and the latter with depression and were observed in 50-week-old mice. Interestingly, the younger CPE-QQ mice (11 weeks old) did not show deficits in dendrite outgrowth and neurogenesis. This study has uncovered a human CPE/NF-α1 gene mutation that could lead to comorbidity of dementia and depression, emphasizing the importance of this gene in cognitive function." @default.
• W2560791331 created "2016-12-16" @default.
• W2560791331 creator A5004643850 @default.
• W2560791331 creator A5004811605 @default.
• W2560791331 creator A5015262039 @default.
• W2560791331 creator A5020788315 @default.
• W2560791331 creator A5031729758 @default.
• W2560791331 creator A5050333430 @default.
• W2560791331 creator A5052627018 @default.
• W2560791331 creator A5071778354 @default.
• W2560791331 date "2016-12-06" @default.
• W2560791331 modified "2023-10-17" @default.
• W2560791331 title "A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer’s disease patient leads to dementia and depression in mice" @default.
• W2560791331 cites W106019808 @default.
• W2560791331 cites W121772056 @default.
• W2560791331 cites W1539992164 @default.
• W2560791331 cites W1711976313 @default.
• W2560791331 cites W1746907828 @default.
• W2560791331 cites W1902317935 @default.
• W2560791331 cites W1950473838 @default.
• W2560791331 cites W1958644126 @default.
• W2560791331 cites W1966799185 @default.
• W2560791331 cites W1969756937 @default.
• W2560791331 cites W1971603181 @default.
• W2560791331 cites W1973774127 @default.
• W2560791331 cites W1981039714 @default.
• W2560791331 cites W2004259334 @default.
• W2560791331 cites W2004385393 @default.
• W2560791331 cites W2017079501 @default.
• W2560791331 cites W2020074950 @default.
• W2560791331 cites W2023703339 @default.
• W2560791331 cites W2029205666 @default.
• W2560791331 cites W2030343090 @default.
• W2560791331 cites W2030772288 @default.
• W2560791331 cites W2036755018 @default.
• W2560791331 cites W2037001270 @default.
• W2560791331 cites W2054978122 @default.
• W2560791331 cites W2055026575 @default.
• W2560791331 cites W2056868493 @default.
• W2560791331 cites W2063710526 @default.
• W2560791331 cites W2064944540 @default.
• W2560791331 cites W2072700625 @default.
• W2560791331 cites W2073483498 @default.
• W2560791331 cites W2077137323 @default.
• W2560791331 cites W2082429191 @default.
• W2560791331 cites W2091250038 @default.
• W2560791331 cites W2093377309 @default.
• W2560791331 cites W2096410114 @default.
• W2560791331 cites W2096963202 @default.
• W2560791331 cites W2097398649 @default.
• W2560791331 cites W2122210899 @default.
• W2560791331 cites W2137392137 @default.
• W2560791331 cites W2138197117 @default.
• W2560791331 cites W2143748931 @default.
• W2560791331 cites W2145796722 @default.
• W2560791331 cites W2148239264 @default.
• W2560791331 cites W2151507730 @default.
• W2560791331 cites W2152387887 @default.
• W2560791331 cites W2163408642 @default.
• W2560791331 cites W2588267526 @default.
• W2560791331 cites W3146038801 @default.
• W2560791331 cites W4211156109 @default.
• W2560791331 cites W47644403 @default.
• W2560791331 cites W827646764 @default.
• W2560791331 doi "https://doi.org/10.1038/tp.2016.237" @default.
• W2560791331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5315563" @default.
• W2560791331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27922637" @default.
• W2560791331 hasPublicationYear "2016" @default.
• W2560791331 type Work @default.
• W2560791331 sameAs 2560791331 @default.
• W2560791331 citedByCount "21" @default.
• W2560791331 countsByYear W25607913312017 @default.
• W2560791331 countsByYear W25607913312018 @default.
• W2560791331 countsByYear W25607913312019 @default.
• W2560791331 countsByYear W25607913312020 @default.
• W2560791331 countsByYear W25607913312021 @default.
• W2560791331 countsByYear W25607913312022 @default.
• W2560791331 countsByYear W25607913312023 @default.
• W2560791331 crossrefType "journal-article" @default.
• W2560791331 hasAuthorship W2560791331A5004643850 @default.
• W2560791331 hasAuthorship W2560791331A5004811605 @default.
• W2560791331 hasAuthorship W2560791331A5015262039 @default.
• W2560791331 hasAuthorship W2560791331A5020788315 @default.
• W2560791331 hasAuthorship W2560791331A5031729758 @default.
• W2560791331 hasAuthorship W2560791331A5050333430 @default.
• W2560791331 hasAuthorship W2560791331A5052627018 @default.
• W2560791331 hasAuthorship W2560791331A5071778354 @default.
• W2560791331 hasBestOaLocation W25607913311 @default.
• W2560791331 hasConcept C108477463 @default.
• W2560791331 hasConcept C126322002 @default.
• W2560791331 hasConcept C134018914 @default.
• W2560791331 hasConcept C169760540 @default.
• W2560791331 hasConcept C181199279 @default.
• W2560791331 hasConcept C2776464000 @default.
• W2560791331 hasConcept C2776925932 @default.
• W2560791331 hasConcept C2779134260 @default.
• W2560791331 hasConcept C2781161787 @default.
• W2560791331 hasConcept C4746552 @default.

• next