Matches in SemOpenAlex for { <https://semopenalex.org/work/W2560820809> ?p ?o ?g. }
- W2560820809 endingPage "17" @default.
- W2560820809 startingPage "13" @default.
- W2560820809 abstract "Neurodegeneration is one of the main physiological consequences of aging on brain. Metallothioneins (MTs), low molecular weight, cysteine-rich proteins that bind heavy-metal ions and oxygen-free radicals, are commonly expressed in various tissues of mammals. MTs are involved in the regulation of cell proliferation and protection, and may be engaged in aging. Expression of the ubiquitous MTs (1 and 2) and the brain specific MT3 have been studied in many neurodegenerative disorders. The research results indicate that MTs may play important, although not yet fully known, roles in brain diseases; in addition, data lack the ability to identify the MT isoforms functionally involved. The aim of this study was to analyse the level of gene expression of selected MT isoforms during brain aging. By using real-time PCR analysis, we determined the MT1/2 and MT3 expression profiles in cerebral cortex and hippocampus of adolescent (2months), adult (4 and 8months), and middle-aged (16months) rats. We show that the relative abundance of all types of MT transcripts changes during aging in both hippocampus and cortex; the first effect is a generalized decrease in the content of MTs transcripts from 2- to 8-months-old rats. After passing middle age, at 16months, we observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, returning to the levels measured in adolescent rats. These findings demonstrate an age-related expression of the MT3 gene. A possible link between the increasing amount of MT3 in brain aging and its different metal-binding behaviour is discussed." @default.
- W2560820809 created "2016-12-16" @default.
- W2560820809 creator A5008429827 @default.
- W2560820809 creator A5056633731 @default.
- W2560820809 creator A5060423670 @default.
- W2560820809 date "2017-01-01" @default.
- W2560820809 modified "2023-09-25" @default.
- W2560820809 title "Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain" @default.
- W2560820809 cites W140828239 @default.
- W2560820809 cites W1494873252 @default.
- W2560820809 cites W1967089050 @default.
- W2560820809 cites W1977813572 @default.
- W2560820809 cites W1979871416 @default.
- W2560820809 cites W1999678879 @default.
- W2560820809 cites W2000509533 @default.
- W2560820809 cites W2009607498 @default.
- W2560820809 cites W2027272551 @default.
- W2560820809 cites W2027452172 @default.
- W2560820809 cites W2030543450 @default.
- W2560820809 cites W2049949159 @default.
- W2560820809 cites W2060892809 @default.
- W2560820809 cites W2063950202 @default.
- W2560820809 cites W2065743337 @default.
- W2560820809 cites W2069473043 @default.
- W2560820809 cites W2084939005 @default.
- W2560820809 cites W2091325970 @default.
- W2560820809 cites W2093336616 @default.
- W2560820809 cites W2102323685 @default.
- W2560820809 cites W2107277218 @default.
- W2560820809 cites W2109762957 @default.
- W2560820809 cites W2118739388 @default.
- W2560820809 cites W2128276881 @default.
- W2560820809 cites W2143546229 @default.
- W2560820809 cites W2153685597 @default.
- W2560820809 cites W2169484100 @default.
- W2560820809 cites W2172520832 @default.
- W2560820809 cites W2172960113 @default.
- W2560820809 cites W2274353398 @default.
- W2560820809 cites W2297272001 @default.
- W2560820809 cites W2511020365 @default.
- W2560820809 cites W4250221563 @default.
- W2560820809 doi "https://doi.org/10.1016/j.crvi.2016.11.003" @default.
- W2560820809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27939232" @default.
- W2560820809 hasPublicationYear "2017" @default.
- W2560820809 type Work @default.
- W2560820809 sameAs 2560820809 @default.
- W2560820809 citedByCount "11" @default.
- W2560820809 countsByYear W25608208092017 @default.
- W2560820809 countsByYear W25608208092018 @default.
- W2560820809 countsByYear W25608208092019 @default.
- W2560820809 countsByYear W25608208092020 @default.
- W2560820809 countsByYear W25608208092022 @default.
- W2560820809 crossrefType "journal-article" @default.
- W2560820809 hasAuthorship W2560820809A5008429827 @default.
- W2560820809 hasAuthorship W2560820809A5056633731 @default.
- W2560820809 hasAuthorship W2560820809A5060423670 @default.
- W2560820809 hasConcept C104317684 @default.
- W2560820809 hasConcept C126322002 @default.
- W2560820809 hasConcept C148762608 @default.
- W2560820809 hasConcept C150194340 @default.
- W2560820809 hasConcept C169760540 @default.
- W2560820809 hasConcept C20719415 @default.
- W2560820809 hasConcept C2776925932 @default.
- W2560820809 hasConcept C2777348757 @default.
- W2560820809 hasConcept C2779134260 @default.
- W2560820809 hasConcept C2781041448 @default.
- W2560820809 hasConcept C2781161787 @default.
- W2560820809 hasConcept C53345823 @default.
- W2560820809 hasConcept C55493867 @default.
- W2560820809 hasConcept C71924100 @default.
- W2560820809 hasConcept C86803240 @default.
- W2560820809 hasConcept C95444343 @default.
- W2560820809 hasConceptScore W2560820809C104317684 @default.
- W2560820809 hasConceptScore W2560820809C126322002 @default.
- W2560820809 hasConceptScore W2560820809C148762608 @default.
- W2560820809 hasConceptScore W2560820809C150194340 @default.
- W2560820809 hasConceptScore W2560820809C169760540 @default.
- W2560820809 hasConceptScore W2560820809C20719415 @default.
- W2560820809 hasConceptScore W2560820809C2776925932 @default.
- W2560820809 hasConceptScore W2560820809C2777348757 @default.
- W2560820809 hasConceptScore W2560820809C2779134260 @default.
- W2560820809 hasConceptScore W2560820809C2781041448 @default.
- W2560820809 hasConceptScore W2560820809C2781161787 @default.
- W2560820809 hasConceptScore W2560820809C53345823 @default.
- W2560820809 hasConceptScore W2560820809C55493867 @default.
- W2560820809 hasConceptScore W2560820809C71924100 @default.
- W2560820809 hasConceptScore W2560820809C86803240 @default.
- W2560820809 hasConceptScore W2560820809C95444343 @default.
- W2560820809 hasIssue "1" @default.
- W2560820809 hasLocation W25608208091 @default.
- W2560820809 hasLocation W25608208092 @default.
- W2560820809 hasOpenAccess W2560820809 @default.
- W2560820809 hasPrimaryLocation W25608208091 @default.
- W2560820809 hasRelatedWork W1501306774 @default.
- W2560820809 hasRelatedWork W2010108080 @default.
- W2560820809 hasRelatedWork W2101607104 @default.
- W2560820809 hasRelatedWork W2138730144 @default.
- W2560820809 hasRelatedWork W2783633930 @default.