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- W2560948612 abstract "Symbiotic bacteria and mucosal immunoglobulins have co-evolved for millions of years in vertebrate animals. Symbiotic bacteria products are known to modulate different aspects of the host immune system. We recently reported that Flectobacillus major is a predominant species that lives in the gill and skin mucosal surfaces of rainbow trout (Oncorhynchus mykiss). F. major is known to produce sphingolipids of a unique molecular structure. Here we propose a role for F. major and its sphingolipids in the regulation of B cell populations in rainbow trout, as well as an essential role for sphingolipids in trout mucosal homeostasis. We found that F. major-specific IgT titers are confined to the gill and skin mucus, whereas F. major-specific IgM titers are only detected in serum. Live F. major cells are able to stimulate sustained IgT expression and secretion in gills. F. major sphingolipids modulate the growth of trout total skin and gill symbiotic bacteria. In vivo systemic administration of F. major sphingolipids changes the proportion of IgT+ to IgM+ B cells in trout HK. These results demonstrate the key role of the symbiont F. major and its sphingolipids in mucosal homeostasis via the modulation of mucosal and systemic Igs and B cells." @default.
- W2560948612 created "2017-01-06" @default.
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- W2560948612 date "2016-12-01" @default.
- W2560948612 modified "2023-10-16" @default.
- W2560948612 title "Symbiont-derived sphingolipids modulate mucosal homeostasis and B cells in teleost fish" @default.
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- W2560948612 doi "https://doi.org/10.1038/srep39054" @default.
- W2560948612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5155239" @default.
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- W2560948612 hasPublicationYear "2016" @default.
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