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- W2560950263 abstract "An LC-MS/MS method was developed for the determination of digitoxigenin in mice skin samples. Chromatographic separation was achieved on an Agilent Poroshell 120 EC-C18 column. Mass spectrometric detection was achieved by a triple-quadrupole mass spectrometer equipped with an ESI interface operating in a positive ionization mode. Quantification was performed using selective reaction monitoring of the precursor-product ion transitions of m/z 375.5→339 for digitoxigenin and m/z 391.5→337 for internal standard (IS). The calibration curves were linear over the concentration range of 1.00-500ng/mL. The intra- and inter-batch precision was no more than 10.6% of the coefficient of variation and the accuracy was within ±8.1% of the actual values. This validated method has been successfully applied to skin permeation and skin metabolic stability studies of digitoxigenin in mice. The steady-state flux and lag time of digitoxigenin permeated across the full-thickness mice skin were 1.86±0.45μg/cm2/h and 0.46±0.18h, respectively. The metabolism of digitoxigenin in the skin was not detected in our study." @default.
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- W2560950263 date "2017-05-01" @default.
- W2560950263 modified "2023-09-27" @default.
- W2560950263 title "An LC–MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies" @default.
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- W2560950263 doi "https://doi.org/10.1016/j.jpba.2016.12.029" @default.
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