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- W2560953325 startingPage "vew033" @default.
- W2560953325 abstract "Arthropod-borne RNA viruses exist within hosts as heterogeneous populations of viral variants and, as a result, possess great genetic plasticity. Understanding the micro-evolutionary forces shaping these viruses can provide insights into how they emerge, adapt, and persist in new and changing ecological niches. While considerable attention has been directed toward studying the population dynamics of mosquito-borne viruses, little is known about tick-borne virus populations. Therefore, using a mouse and Ixodes scapularis tick transmission model, we examined Powassan virus (POWV; Flaviviridae, Flavivirus) populations in and between both the vertebrate host and arthropod vector. We found that genetic bottlenecks, RNAi-mediated diversification, and selective constraints collectively influence POWV evolution. Together, our data provide a mechanistic explanation for the slow, long-term evolutionary trends of POWV, and suggest that all arthropod-borne viruses encounter similar selective pressures at the molecular level (i.e. RNAi), yet evolve much differently due to their unique rates and modes of transmission." @default.
- W2560953325 created "2017-01-06" @default.
- W2560953325 creator A5003615801 @default.
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- W2560953325 date "2016-07-01" @default.
- W2560953325 modified "2023-10-04" @default.
- W2560953325 title "Transmission bottlenecks and RNAi collectively influence tick-borne flavivirus evolution" @default.
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- W2560953325 doi "https://doi.org/10.1093/ve/vew033" @default.
- W2560953325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5210029" @default.
- W2560953325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28058113" @default.
- W2560953325 hasPublicationYear "2016" @default.
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