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• W2560953521 abstract "Abstract Taking into consideration the importance of the photooxidative effects in complex bio- environments, this paper reports on the visible-light-promoted interactions between Evernyl (methyl 2, 4-dihydroxy-3,6-dimethylbenzoate, Ev) and vitamin B2 (riboflavin, Rf). Ev is a phenolic derivative, transparent to visible light, that possesses important antimicrobial activity. This compound is the first known natural, complete and specific human androgen receptor antagonist. Ev is profusely employed in personal-care products and synthesized as a secondary metabolite by several lichen and plant species. In both sceneries, acting Ev as a cosmetic component for topic applications or as a lichen constituent, may Rf behave as a native visible-light absorber pigment. In this context, kinetic and mechanistic aspects of the Rf-sensitized photooxidation of Ev, has been studied in aqueous solution, irradiating with blue LED light (463–471 nm) and employing stationary and time resolved methods. Results indicate that Ev reacts with the photogenerated reactive oxygen species (ROS) singlet molecular oxygen with a rate constant of k r =1.1±0.2×10 6 M −1 s −1 . In parallel Ev also quenches the electronically excited singlet and triplet excited states of Rf with rate constants close to the difussion limit. As a result the ROS superoxide radical anion and hydrogen peroxide are generated and the latter subsequently reacts with Ev. Possible implications of these photoreactions on the antimicrobial activity of Ev have been investigated employing a Candida albicans (CA) strain, isolated from human skin infection. The simultaneous presence of Rf, Ev in a sub-MIC, and blue-light irradiation produced a significant antimycotic effect, attributed to ROS photogeneration." @default.
• W2560953521 created "2017-01-06" @default.
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• W2560953521 date "2015-10-01" @default.
• W2560953521 modified "2023-10-16" @default.
• W2560953521 title "Vitamin B2-sensitized degradation of the multifunctional drug Evernyl, in the presence of visible light – microbiological implications" @default.
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• W2560953521 doi "https://doi.org/10.1515/pac-2015-0407" @default.
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