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• W2560994037 abstract "We isolated and characterized embryonic lethal mutations in piragua ( prg ). The prg locus encodes a protein with an amino terminus Zinc Finger-Associated-Domain (ZAD) and nine C 2 H 2 zinc fingers (ZF). prg mRNA and protein expression during embryogenesis is dynamic with widespread maternal contribution, and subsequent expression in epithelial precursors. About a quarter of prg mutant embryos do not develop cuticle, and from those that do a small fraction have cuticular defects. Roughly half of prg mutants die during embryogenesis. prg mutants have an extended phenocritical period encompassing embryogenesis and first instar larval stage, since the other half of prg mutants die as first or second instar larvae. During dorsal closure, time-lapse high-resolution imaging shows defects arising out of sluggishness in closure, resolving at times in failures of closure. prg is expressed in imaginal discs, and is required for imaginal development. prg was identified in imaginal tissue in a cell super competition screen, together with other genes, like flower . We find that flower mutations are also embryonic lethal with a similar phenocritical period and strong embryonic mutant phenotypes (head involution defects, primarily). The two loci interact genetically in the embryo, as they increase embryonic mortality to close to 90% with the same embryonic phenotypes (dorsal closure and head involution defects, plus lack of cuticle). Mutant prg clones generated in developing dorsal thorax and eye imaginal tissue have strong developmental defects (lack of bristles and ommatidial malformations). prg is required in several developmental morphogenetic processes. • piragua , a ZAD-ZF protein, regulates developmental processes in embryos and imaginal tissue. • piragua mutants disrupt embryogenesis displaying sluggish developmental kinetics. • piragua mutants interact with flower during embryogenesis." @default.
• W2560994037 created "2017-01-06" @default.
• W2560994037 creator A5038603508 @default.
• W2560994037 creator A5080904247 @default.
• W2560994037 date "2017-04-01" @default.
• W2560994037 modified "2023-09-24" @default.
• W2560994037 title "piragua encodes a zinc finger protein required for development in Drosophila" @default.
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• W2560994037 doi "https://doi.org/10.1016/j.mod.2016.12.003" @default.
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