FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561008093> ?p ?o ?g. }

• W2561008093 endingPage "9387" @default.
• W2561008093 startingPage "9375" @default.
• W2561008093 abstract "The potent ability of CRISPR/Cas9 system to inhibit the expression of targeted gene is being exploited as a new class of therapeutics for a variety of diseases. However, the efficient and safe delivery of CRISPR/Cas9 into specific cell populations is still the principal challenge in the clinical development of CRISPR/Cas9 therapeutics. In this study, a flexible aptamer-liposome-CRISPR/Cas9 chimera was designed to combine efficient delivery and increased flexibility. Our chimera incorporated an RNA aptamer that specifically binds prostate cancer cells expressing the prostate-specific membrane antigen as a ligand. Cationic liposomes were linked to aptamers by the post-insertion method and were used to deliver therapeutic CRISPR/Cas9 that target the survival gene, polo-like kinase 1, in tumor cells. We demonstrate that the aptamer-liposome-CRISPR/Cas9 chimeras had a significant cell-type binding specificity and a remarkable gene silencing effect in vitro. Furthermore, silencing promoted a conspicuous regression of prostate cancer in vivo. Importantly, the approach described here provides a universal means of cell type-specific CRISPR/Cas9 delivery, which is a critical goal for the widespread therapeutic applicability of CRISPR/Cas9 or other nucleic acid drugs." @default.
• W2561008093 created "2017-01-06" @default.
• W2561008093 creator A5001695955 @default.
• W2561008093 creator A5004302628 @default.
• W2561008093 creator A5015202222 @default.
• W2561008093 creator A5076091833 @default.
• W2561008093 creator A5080540007 @default.
• W2561008093 date "2016-12-21" @default.
• W2561008093 modified "2023-09-30" @default.
• W2561008093 title "Targeted delivery of CRISPR/Cas9 to prostate cancer by modified gRNA using a flexible aptamer-cationic liposome" @default.
• W2561008093 cites W1435110089 @default.
• W2561008093 cites W1710257910 @default.
• W2561008093 cites W1965905029 @default.
• W2561008093 cites W1976391205 @default.
• W2561008093 cites W1979954728 @default.
• W2561008093 cites W2002961521 @default.
• W2561008093 cites W2038659500 @default.
• W2561008093 cites W2058735345 @default.
• W2561008093 cites W2063148079 @default.
• W2561008093 cites W2067119305 @default.
• W2561008093 cites W2068427957 @default.
• W2561008093 cites W2071745634 @default.
• W2561008093 cites W2087898800 @default.
• W2561008093 cites W2118412890 @default.
• W2561008093 cites W2123175900 @default.
• W2561008093 cites W2146029618 @default.
• W2561008093 cites W2155192875 @default.
• W2561008093 cites W2156983262 @default.
• W2561008093 cites W2158537784 @default.
• W2561008093 cites W2209731801 @default.
• W2561008093 cites W2298491177 @default.
• W2561008093 cites W97126099 @default.
• W2561008093 doi "https://doi.org/10.18632/oncotarget.14072" @default.
• W2561008093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5354738" @default.
• W2561008093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28030843" @default.
• W2561008093 hasPublicationYear "2016" @default.
• W2561008093 type Work @default.
• W2561008093 sameAs 2561008093 @default.
• W2561008093 citedByCount "85" @default.
• W2561008093 countsByYear W25610080932017 @default.
• W2561008093 countsByYear W25610080932018 @default.
• W2561008093 countsByYear W25610080932019 @default.
• W2561008093 countsByYear W25610080932020 @default.
• W2561008093 countsByYear W25610080932021 @default.
• W2561008093 countsByYear W25610080932022 @default.
• W2561008093 countsByYear W25610080932023 @default.
• W2561008093 crossrefType "journal-article" @default.
• W2561008093 hasAuthorship W2561008093A5001695955 @default.
• W2561008093 hasAuthorship W2561008093A5004302628 @default.
• W2561008093 hasAuthorship W2561008093A5015202222 @default.
• W2561008093 hasAuthorship W2561008093A5076091833 @default.
• W2561008093 hasAuthorship W2561008093A5080540007 @default.
• W2561008093 hasBestOaLocation W25610080931 @default.
• W2561008093 hasConcept C104317684 @default.
• W2561008093 hasConcept C111599444 @default.
• W2561008093 hasConcept C119056186 @default.
• W2561008093 hasConcept C121608353 @default.
• W2561008093 hasConcept C128972844 @default.
• W2561008093 hasConcept C132455925 @default.
• W2561008093 hasConcept C144501496 @default.
• W2561008093 hasConcept C153911025 @default.
• W2561008093 hasConcept C2780192828 @default.
• W2561008093 hasConcept C30278631 @default.
• W2561008093 hasConcept C502942594 @default.
• W2561008093 hasConcept C54355233 @default.
• W2561008093 hasConcept C70721500 @default.
• W2561008093 hasConcept C86803240 @default.
• W2561008093 hasConcept C98108389 @default.
• W2561008093 hasConceptScore W2561008093C104317684 @default.
• W2561008093 hasConceptScore W2561008093C111599444 @default.
• W2561008093 hasConceptScore W2561008093C119056186 @default.
• W2561008093 hasConceptScore W2561008093C121608353 @default.
• W2561008093 hasConceptScore W2561008093C128972844 @default.
• W2561008093 hasConceptScore W2561008093C132455925 @default.
• W2561008093 hasConceptScore W2561008093C144501496 @default.
• W2561008093 hasConceptScore W2561008093C153911025 @default.
• W2561008093 hasConceptScore W2561008093C2780192828 @default.
• W2561008093 hasConceptScore W2561008093C30278631 @default.
• W2561008093 hasConceptScore W2561008093C502942594 @default.
• W2561008093 hasConceptScore W2561008093C54355233 @default.
• W2561008093 hasConceptScore W2561008093C70721500 @default.
• W2561008093 hasConceptScore W2561008093C86803240 @default.
• W2561008093 hasConceptScore W2561008093C98108389 @default.
• W2561008093 hasIssue "6" @default.
• W2561008093 hasLocation W25610080931 @default.
• W2561008093 hasLocation W25610080932 @default.
• W2561008093 hasLocation W25610080933 @default.
• W2561008093 hasLocation W25610080934 @default.
• W2561008093 hasLocation W25610080935 @default.
• W2561008093 hasOpenAccess W2561008093 @default.
• W2561008093 hasPrimaryLocation W25610080931 @default.
• W2561008093 hasRelatedWork W2147256573 @default.
• W2561008093 hasRelatedWork W2527347512 @default.
• W2561008093 hasRelatedWork W2770152187 @default.
• W2561008093 hasRelatedWork W2898208578 @default.
• W2561008093 hasRelatedWork W2900771990 @default.
• W2561008093 hasRelatedWork W2943124855 @default.
• W2561008093 hasRelatedWork W2953290252 @default.

• next