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- W2561150112 abstract "Hyptis suaveolens (L.) Poit (Labiatae), called in Thai as “ Maeng Luk Kha”, is well-known among Northern Thais for its anti-itching property. Part of the plant used for folklore remedies is leaves. The major chemical constituents containing in H. suaveolens oil were sabinene, β-caryophyllene,1, 8-cineole (Peerzada, 1997, Azevedo et al. 2001). H. suaveolens was reported to be of therapeutic value as a carminative, antiseptic, sudorific and galactagogue (Saluja and Santani, 1993). According to its dermal effect, there are some evidence which support this activity. Iwu et al. (1990) demonstrated that essential oil isolated from H. suaveolens inhibited the growth of both gramnegative and gram-positive bacteria as well as some fungi, Candida albican and Aspergillus niger. Fungiotoxicity of H. suaveolens oil against Aspergillus flavus has also been reported by Mishra and Dubey (1994). Additionally, marked antimicrobial activity of the oil against Staphylococcus aureus, Trichophyton mentagrophytes and Trichophyton rubrum was reported (Titawan et al., 2004). Thus, the oil was initially prepared as topical cream for therapeutic use in skin infection. It has also been found that topical creams containing 10%, 20% and 30% of H. suaveolens oil possessed antimicrobial activity against S. aureus, T. mentagrophytes and T. rubrum (Titawan et al., 2004). For safety reason, the toxicity of H. suaveolens cream needs to be investigated before application in human. Therefore, this study was carried out in order to assess possible toxicity of H. suaveolens cream in various concentrations from repeated exposure by the dermal route over a certain period of time in rats." @default.
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- W2561150112 date "2007-01-01" @default.
- W2561150112 modified "2023-09-24" @default.
- W2561150112 title "Safety of Topical Formulations Containing Hyptis suaveolens Bioactive Compound" @default.
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